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1. Introduction
2. Acknowledgments
3. Type 1 Diabetes
4. Classic view of type 1 diabetes
5. Autoimmune disease: a minimal model
6. Age at diagnosis of autoimmune diabetes
7. Type 1 diabetes associated genes
8. Evidence for non-genetic effects
9. Type 1 diabetes in identical twins
10. Evidence for non-genetic effects: MZ twins
11. Minimal model - tissue inflammation
12. Early induction of islet cell antibodies
13. Multiple islet autoantibodies role in the disease
14. Minimal model - events occur before inflammation
15. Serum CML in a general population
16. An AGE predicts autoimmune diabetes
17. Serum biomarkers for autoimmune diabetes
18. Minimal model - events occur after inflammation
19. Type 1 diabetes is not acute
20. Adult-onset autoimmune diabetes
21. GADA positive patients (LADA)
22. GADA is the dominant autoantibody in LADA
23. Adult-onset autoimmune diabetes (2)
24. Autoimmune type 1 diabetes
25. IL-6 in LADA
26. Inflammation and diabetes
27. Peak value of C-peptide as a function of age
28. Action LADA metabolic syndrome
29. Autoimmune diabetes spectrum
30. Challenging the classical view of type 1 diabetes

Topics Covered

• Autoimmunity is induced in early life
• Autoimmunity involves non-genetic effects which occur in childhood
• At least 2 non-genetic effects are involved in predisposing to type 1 diabetes
• The age at which autoimmune diabetes is diagnosed affects the clinical and immunogenetic pattern of the disease
• Autoimmune diabetes in adults in Europe as in China is the most prevalent form of autoimmune diabetes

Links

Series:

• Diabetes in Perspective

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on May 22, 2013
• Archived on October 31, 2021

Financial Disclosures

• The speaker sits on the advisory board for Abbott, Sanofi, Roche, Novo-Nordisk and Diamyd. He receives funding from the EU, EFSD, Barts Charity and Diabetic Twin Trust.