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Printable Handouts
Navigable Slide Index
- Introduction
- Is type 1 diabetes still increasing?
- Increase in type 1 diabetes
- Diabetes in children
- Etiology of type 1 diabetes
- Genetic etiology
- Cells damaged by type 1 diabetes
- Markers of islet autoimmunity
- Type 1 diabetes is a two step disease
- Generation of autoimmunity
- HLA-DQ8 and insulin
- HLA-A2 and insulin
- B lymphocytes and autoantibodies
- Preservation of insulin secretion with Rituximab
- MHC class II variability
- Intermediate summary
- The TEDDY study
- Screening genotypes
- Enrollment by HLA genotype to the TEDDY study
- TEDDY follow up protocol
- TEDDY children with islet autoantibodies
- Multiple islet autoantibodies
- Finnish children develop autoantibodies earlier
- Persistent islet autoimmunity: 1st degree relatives
- Contribution of gestational infections
- Future studies
- Pathogenesis of type 1 diabetes
- After birth triggers and accelerators
- T1D children by site
- DTP1 study: Number of antibodies and risk
- A subject in DiPiS – Diabetes after 9 years
- HLA class II presents antigens
- Antigen recognition by CD8+ T cells
- Insulitis and onset of hyperglycemia
- Predictability of type 1 diabetes
- DTP1 study once again
- Type 1 diabetes can be predicted
- Diabetic ketoacidosis (DKA) prevalence
- Diabetic ketoacidosis reference paper
- DKA results from several recent studies
- OGTT and T1D
- Conclusions
- Acknowledgements (1)
- Acknowledgements (2)
Topics Covered
- Type 1 diabetes is an autoimmune disease
- Specific eradication of pancreatic beta cells
- Environmental factors that trigger the appearance of islet autoantibodies
- The pathogenesis involve factors that either accelerate or decelerate progression to clinical onset of diabetes
- A combination of genetic typing for HLA genes and determination of islet autoantibodies make type 1 diabetes a predictable disease
Links
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Therapeutic Areas:
Talk Citation
Lernmark, Å. (2013, May 22). What is new in type 1 diabetes? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/HUGK5030.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Åke Lernmark, Consultant: Diamyd Medicals AB, Stockholm, Sweden ; Grant/Research Support (Principal Investigator): National Institutes of Health, Swedish Council, Juvenile Diabetes Research Foundation.
A selection of talks on Cardiovascular & Metabolic
Transcript
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0:00
What is new in type I diabetes?
Ake Lernmark, Lunds University,
Skanes University Hospital in Malmo.
0:13
What is new in type I diabetes?
Is the disease still increasing?
0:21
As can be seen from slide three,
type I diabetes is increasing
by 3-5% per year.
The slide is showing examples from Finland,
which has the highest incidence rate
in the world
followed by Sweden, and Colorado and Germany are
illustrated as countries which also show
an increased incidence rate.
The highest incidence rate per year
presently known is in Poland with 14%
increase per year.
1:09
This world map on slide four depicts new cases
of type I diabetes in children
0-14 years in age.
And as can be seen, Scandinavia and the Northern Hemisphere
or Southern Hemisphere in Australia and New Zealand
have an increased rate of type 1 diabetes.
More alarmingly is the fact that
type I diabetes is becoming more and more common
in developing countries where
the incidence rate is increasing.