Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. What are the unmet needs in TB therapy?
4. TB is a global disease
5. TB is a multidimensional problem
6. Current TB therapies - active TB
7. Current TB therapies - latent TB
8. Unmet needs in TB therapy
9. Desired regimen profiles
10. The approaches in TB drug development
11. Process for TB drug development
12. Conventional approach 1
13. Conventional approach 2
14. Conventional approach: issues
15. New approach
16. Process for novel regimen development
17. New approach: advantages and challenges
18. How to identify novel TB regimens
19. Drug classes available for regimen development
20. Drug to regimen
21. Mouse infection model
22. PaMZ - bactericidal activity in mouse model
23. PaMZ - sterilizing activity in mouse model
24. PaMZ - combination EBA design (NC-001)
25. PaMZ - combination EBA results (NC-001)
26. Summary
27. Thank you!

Topics Covered

• Current therapies against tuberculosis and unmet needs
• Desired profile for new TB drug regimen
• Current approaches in TB drug development
• New approaches in TB regimen development

Links

Series:

• Tuberculosis

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases
• Respiratory Diseases

Talk Citation

Publication History

• Published on February 28, 2013

Financial Disclosures

• Dr. Zhenkun Ma has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.