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1. Introduction
2. Schematic diagram of an ischemic stroke
3. Astrocyte neuroprotection (1)
4. P2Y1R stimulation reduces RB infarcts (1)
5. P2Y1R stimulation reduces RB infarcts (2)
6. In vivo optical imaging of mouse parietal cortex
7. Cerebral ischemic stroke in living mouse
8. BBB disruption induced by RB photothrombosis
9. Pre photothrombosis (1)
10. 24 hours post photothrombosis
11. 48 hours post photothrombosis
12. Necrotic core is not anoxic
13. ATP production in astrocytes
14. Ischemic ATP production in astrocytes
15. ATP production in neurons
16. Pre photothrombosis (2)
17. 24 hours post photothrombosis (2MeSADP) (1)
18. 48 hours post photothrombosis (2MeSADP) (2)
19. Pre photothrombosis (3)
20. 24 hrs after stroke (2MeSADP added)
21. 48 hrs after stroke (24 hrs after 2MeSADP added)
22. Astrocyte neuroprotection (2)
23. Fluoroacetate blocks P2Y1R protection
24. MtEcoRI affects the mitochondria potential delta
25. P2Y1R-enhanced neuroprotection
26. Gradient cell swelling towards thrombosis
27. Swelling 3 hours post photothrombosis
28. Cell swelling in more details
29. Cell swelling with 2MeSADP
30. Ischemia induces astrocyte death
31. Astrocyte swelling is reversible
32. Astrocyte neuroprotection (3)
33. P2Y1R decreases brain swelling following TBI
34. P2Y1R decreases cell edema in hippocampus
35. Astrocyte neuroprotection (4)
36. Acknowledgements

Topics Covered

• Schematic diagram of an ischemic stroke at cellular level
• P2Y1-R stimulation
• Photothrombosis
• Pathways involved in ATP production in astrocytes
• Working model of astrocyte neuroprotection
• Ischemia-induced astrocyte cell swelling

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Lechleiter, J. (2013, February 17). The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/LBOD2831.
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Publication History

• Published on February 17, 2013

Financial Disclosures

• Prof. James Lechleiter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.