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• 68 min
  1. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

  • Prof. Emeritus Siamon Gordon
• 25 min
  2. Biosimilars: when value meets cost

  • Prof. Fernando de Mora
• 25 min
  3. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  4. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  5. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  6. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  7. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  8. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  9. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  10. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  11. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  12. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  13. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  14. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  15. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  16. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  17. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  18. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  19. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  20. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  21. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  22. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  23. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  24. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  25. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  26. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  27. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  28. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  29. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Lecture outline
3. Macrophages - general attributes
4. Macrophages and receptor recognition
5. CD36 structure
6. CD36: regions within the protein
7. CD36: function and membrane distribution
8. CD36: a multifunctional membrane glycoprotein (1)
9. CD36: a multifunctional membrane glycoprotein (2)
10. Atherogenesis and monocytes/macrophages
11. A tale of two mice
12. Experimental design of atherosclerosis in mice
13. The aortic tree in mice and humans
14. Absence of CD36 & atherosclerosis in apoEo mice
15. ApoEo vs. ApoEo/CD36o: degree of lesions
16. Lesions in LDLRo mice are not CD36 dependent
17. LDLRo vs. LDLRo/CD36o lesion burden
18. Foam cell formation in LDLRo is CD36 dependent
19. CD36 may not be the atherogenic ligand in LDLRo
20. In vivo foam cell assay
21. The ligand in the 2 mouse models differs
22. Ligand may differ in a CD36 dependent manner
23. Making the LDL in the LDLRo a ligand for CD36
24. LDLRo vs. CD36o/LDLRo + high cholesterol diet
25. LDLR KO's: hyperlipidemia and inflammation
26. Inflammation, CD36 ligands and atherosclerosis
27. CD36 specific ligands in oxidatively modified LDL
28. CD36 ligands are choline glycerophospholipids
29. How CD36 detects differences in phospholipids
30. Multiple pathways may create CD36R ligands
31. Recognition of altered self ligands by CD36
32. Summary
33. Acknowledgements

Topics Covered

• Scavenger receptors
• Structure of CD36
• Role of CD36
• The link between inflammation and CD36
• Risk factors for inflammation

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation

Talk Citation

Publication History

• Published on January 30, 2013

Financial Disclosures

• Dr. Maria Febbraio has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.