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0:00
Biomarkers in osteoarthritis.
Ali Mobasheri.
0:06
The aim of this presentation
is to provide an overview
of current research on
osteoarthritis biomarkers.
Highlight the lack of
analytical tools and
reagents in our currently
available toolbox.
Discuss the limitations of
currently available biomarkers.
We will also explore future
opportunities and identify
key areas that are relevant to
the pharmaceutical
product pipeline.
0:30
This presentation will
summarise the definition
of osteoarthritis and the
biomarkers of osteoarthritis
and highlights the need for
a better "gold standard"
because radiography is
currently inadequate.
The presentation
will also discuss
recent developments in
biomarker definition
and classification and
introduce the concepts
of "wet" and "dry" biomarkers.
I will also discuss
post-genomic approaches
for the identification of new
osteoarthritis biomarkers
aimed at early pre-radiographic
identification of disease.
I will discuss the advent of
"combination biomarkers".
1:07
Before discussing biomarkers
of osteoarthritis,
I will need to provide some
background information
about osteoarthritis.
1:16
Osteoarthritis is the most
common form of arthritis
in humans and companion animals,
and it is a major cause
of pain, inflammation
and loss of mobility.
1:28
Osteoarthritis is
characterised by
progressive deterioration
and loss of articular cartilage.
It affects load-bearing
synovial joints
and is associated with ageing
and excessive or
abnormal joint loading.
