• Introduction to Calcium Signaling
• 72 min
  1. Introduction to cellular calcium signaling

  • Dr. Martin Bootman
• 20 min
  2. Monitoring Ca2+ concentration in living cells

  • Dr. Marisa Brini
• 30 min
  3. Cell boundary theorem

  • Prof. Eduardo Ríos
• Calcium Influx
• 19 min
  4. Arachidonic acid and store-independent Ca2+ entry

  • Dr. Luca Munaron
• 34 min
  5. Voltage-dependent calcium channels

  • Prof. Annette Dolphin
• 34 min
  6. Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling

  • Prof. Bernd Fakler
• 37 min
  7. Intracellular Ca2+ signaling: calcium influx

  • Prof. Anant Parekh
• 60 min
  8. Molecular identification of the CRAC channel

  • Prof. Michael Cahalan
• 35 min
  9. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility

  • Prof. Marc Freichel
• Calcium Release
• 47 min
  10. The molecular biology of the inositol trisphosphate receptor

  • Dr. Randen Patterson
• 53 min
  11. The InsP3 receptor calcium release channel

  • Prof. J. Kevin Foskett
• 31 min
  12. Molecular biology of ryanodine receptors

  • Dr. Christopher George
  • Prof. F. Anthony Lai
• 57 min
  13. cADPR and NAADP: messengers for calcium signalling

  • Prof. Antony Galione
• 50 min
  14. Coordinated Ca2+ release from intracellular Ca2+ stores

  • Prof. Ole Petersen
• 43 min
  15. Ryanodine receptors and cardiac function

  • Prof. David Eisner
• Calcium Efflux and Sequestration
• 45 min
  16. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology

  • Prof. Ernesto Carafoli
• 60 min
  17. The calcium saga: a matter of life and death

  • Prof. Pierluigi Nicotera
• 45 min
  18. Sodium-calcium exchange

  • Prof. John Reeves
• 22 min
  19. Ca2+ efflux and Ca2+ signals

  • Dr. Anne Green
• Organelle Calcium
• 42 min
  20. Regulation and role of mitochondrial Ca2+ homeostasis

  • Prof. Rosario Rizzuto
• 54 min
  21. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis

  • Dr. Paola Pizzo
  • Dr. Alex Costa
• 31 min
  22. Organellar calcium pumps of the golgi and ER: from yeast to human

  • Prof. Rajini Rao
• 34 min
  23. Ca2+ dynamics between mitochondria and the endoplasmic reticulum

  • Dr. Wolfgang Graier
• 26 min
  24. Nuclear calcium signaling

  • Dr. Oleg Gerasimenko
  • Dr. Julia Gerasimenko
• Spatiotemporal Calcium Signals
• 58 min
  25. Spatial and temporal aspects of cellular calcium signals: 'elementary' signals and waves

  • Prof. Ian Parker
• 54 min
  26. Regulation of intracellular calcium signaling, localized signals and oscillations

  • Prof. Barbara Ehrlich
• 26 min
  27. Modeling Ca2+ signals

  • Dr. David Friel
• Calcium Effectors
• 34 min
  28. Neuronal calcium sensor proteins: calcium sensors and regulators of diverse cellular functions

  • Prof. Bob Burgoyne
• 41 min
  29. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

  • Prof. Dermot Cooper
• 32 min
  30. Calcium and transcription-coupling

  • Dr. Karen Lounsbury
• 50 min
  31. Cellular calcium (Ca2+) buffers

  • Prof. Dr. Beat Schwaller
• 24 min
  32. Extracellular calcium signaling

  • Dr. Aldebaran M. Hofer
• 50 min
  33. Ca2+, fertilization and egg activation

  • Prof. Karl Swann
• 24 min
  34. Calcium regulation of transcription in plants

  • Prof. Hillel Fromm
• 34 min
  35. Mechanisms regulating STIM expression and function in Ca2+ signaling

  • Dr. Jonathan Soboloff
• 46 min
  36. Dynamic signal encoding in the S. cerevisiae calcium response

  • Dr. Chiraj Dalal
• Calcium and Disease
• 43 min
  37. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 28 min
  38. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 38 min
  39. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 47 min
  40. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 46 min
  41. Genetic defects and calcium

  • Prof. Tullio Pozzan
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  42. Calcium, calmodulin and calcineurin

  • Prof. Stephen Bolsover
• 34 min
  43. Calcium flickers steer cell migration

  • Prof. Heping Cheng
• 28 min
  44. Automated Ca2+ imaging of chemosensory neurones in C.elegans

  • Dr. Nikos Chronis
• 46 min
  45. Ca2+ and the regulation of small GTPases

  • Prof. Peter Cullen
• 35 min
  46. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo

  • Dr. Michael I. Kotlikoff
• 35 min
  47. Capacitative (store-operated) calcium entry

  • Dr. Jim Putney

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Major intracellular signal transduction pathways
3. Ca2+ influx and efflux and extracellular Ca2+
4. Topics
5. Systemic Ca2+ homeostasis
6. Extracellular Ca2+ sensing receptor (CaR)
7. Mutations in the human CaR
8. CaSR KO in animals
9. Partial list of cell types expressing CaR
10. The CaR is a promiscuous receptor
11. CaR signaling pathways
12. Cells transfected with CaR and ratiometric pericam
13. How and when [Ca2+] fluctuates locally
14. Extracellular Ca associated with intracellular Ca
15. Ca fluxes across plasma membrane
16. Measurements of Ca-out in cells expressing CaR
17. Ca accumulation outside following Ca spike
18. Oscillations in external [Ca2+]?
19. Ca diffusion in real tissues is more limited
20. Measuring Ca using selective micro-electrodes
21. Carbachol causes decreases in basolateral [Ca]
22. Carbachol causes increases in luminal [Ca]
23. Ca movements across the tissues
24. Some ways in which local [Ca2+]out can change
25. Other extracellular Ca2+ "sensors"
26. Ca2+ as a paracrine messenger?
27. Ca2+ as a local extracellular messenger
28. Co-culture model system (1)
29. Co-culture model system (2)
30. Response of "sensor cell"
31. Ca2+ as an autocrine signaling molecule
32. Physiological importance of fluctuations in [Ca]
33. [Ca2+]out affects alkaline secretion
34. Extracellular [Ca2+] necessary for full response
35. Acknowledgment

Topics Covered

• Local accumulations and depletions of extracellular Calcium
• Systemic Calcium homeostasis
• Extracellular Ca2+ sensing receptor (CaR)
• Mutations in the human CaR
• How and when Calcium fluctuates locally
• Calcium fluxes across the plasma membrane during calcium signals can be significant
• Oscillations in external Calcium
• Ca2+ selective microelectrodes
• The effect of Carbachol
• Ways in which local [Ca2+]out can change
• Extracellular Ca2+ "sensors"
• Ca2+ as a paracrine messenger
• Ca2+ as a local extracellular messenger
• Co-culture model system
• Ca2+ as an autocrine signaling molecule
• Evidence for the physiological importance of fluctuations in [Ca2+]out
• [Ca2+]out affects alkaline secretion

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on December 18, 2012
• Reviewed on August 12, 2020

Financial Disclosures

• Dr. Aldebaran M. Hofer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.