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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Gamma C family cytokines
- Importance of gamma C cytokines
- Cytokines
- Type I and type II cytokines
- Type I cytokines
- GH/GHR complex
- IL-2
- IL-2 receptors
- IL-2 - IL2R interaction
- The high affinity IL-2 receptor
- Two receptor components in gamma C cytokines
- The expanded "IL-2 family" of cytokines
- X-linked severe combined immunodeficiency
- Basis for T, NK, and B-cell defects in XSCID
- Why share gamma C? (1)
- Why share gamma C? (2)
- Why share gamma C? (3)
- Cytokine pleiotropy and redundancy
- Cytokine receptor pleiotropy and redundancy
- IL-2 activates multiple signaling pathways
- JAK-STAT pathway
- Pleiotropic use of JAKs
- Causes of T-B+NK- and T-B+NK+ SCID
- What is the basis for signaling specificity?
- Pleiotropic use of STATs
- Gamma C family cytokine sources - summary
- Actions of IL-2
- Therapy related to IL-2
- Activities of IL-4
- Activities of IL-7
- Activities of IL-9
- Activities of IL-15
- Pleiotropic actions of IL-21
- Activities of IL-21
- Clinical potential of IL-21
- Cells with receptor chains for gamma C cytokines
- Summary
- Acknowledgements
Topics Covered
- The gamma c family of cytokines
- General features of cytokines
- Cytokine and cytokine receptor pleiotropy and redundancy
- The gamma c family of cytokines and its relationship to X-linked severe combined immunodeficiency
- Features of gamma c family cytokines (IL-2, IL-4, IL-9, IL-9, IL-15, and IL-21)
- Clinical potential of gamma c cytokines
Talk Citation
Leonard, W.J. (2012, December 18). The gamma c family of cytokines [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/NAER1519.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Warren J. Leonard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.