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1. Introduction
2. Yeast cell wall
3. Contents
4. Graphical conventions for glycans
5. Composition of yeast cell walls
6. Architecture of yeast cell walls
7. Yeast glycan structures
8. Structure and biosynthesis of beta1,3 glucan
9. Beta1,3 glucan synthesis
10. Regions of Fks1 glucan synthetase
11. Chitin
12. Chitin synthesis
13. Branched beta1,6 glucan
14. Beta1,6 glucan crosslinks other wall components
15. Mannoprotein layer
16. Localization of different cell wall proteins
17. Candida albicans Als adhesins
18. Mannoproteins
19. A short N-linked chain and a Man4 O-linked chain
20. Biosynthesis of N-glycans
21. Glycosyl phosphatydyl inositol (GPI) synthesis
22. Secretory pathway for GPI-crosslinked proteins
23. Mannoprotein crosslinks to glucan
24. Pir protein glutamyl-glucan esters
25. GPI-dependent anchorage to glucan
26. Cell wall biosynthesis and assembly 2012
27. Dynamics - genetic regulation
28. Dynamics - budding and septation
29. Dynamics - mating
30. Surface amyloid-mediated mannoprotein clustering
31. Generality and evolution
32. Recap
33. Bibliography

Topics Covered

• The overall architecture of yeast cell walls and the roles of glycans
• Structure and biosynthesis of major cell wall components
• A scheme for cell wall assembly and crosslinking
• Cell wall dynamics in growth, budding, stress response, cell adhesion, and mating
• Cell wall structure in other fungi and a relationship among eukaryotic extracellular matrices

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology
• Microbiology

Talk Citation

Publication History

• Published on November 27, 2012

Financial Disclosures

• Dr. Peter Lipke, Grant/Research Support (Principal Investigator): I hold a grant from Biothera, the Immune Health Company. Their products are neither mentioned nor promoted in the lecture.