• The Basics of Glycan Structure, Biosynthesis, and Function
• 28 min
  1. Use of heparosan polysaccharide to enhance drug delivery

  • Prof. Paul L. DeAngelis
• 31 min
  2. Recognition of 'self' and 'non-self' glycans by carbohydrate-binding proteins: structural and functional aspects

  • Prof. Gerado Vasta
• 49 min
  3. O-GlcNAc, an essential regulator of numerous cellular pathways

  • Dr. Natasha Zachara
• 58 min
  4. Plant cell wall: structure and biosynthesis

  • Prof. Debra Mohnen
  • Dr. Melani A. Atmodjo
• 51 min
  5. GPI-anchored glycoproteins

  • Prof. Michael Ferguson
• 52 min
  6. The role of bacterial carbohydrates in microbe-plant interactions: Rhizobium- legume nitrogen-fixing symbiosis

  • Prof. Russell Carlson
• 51 min
  7. Structure of cell walls in yeast and other fungi

  • Dr. Peter Lipke
• Glycan Regulation and Function in Development and Physiology
• 49 min
  8. Function of carbohydrate recognition by C-type lectins on dendritic cells in “host defence” and “immune homeostasis”

  • Dr. Yvette Van Kooyk
• 23 min
  9. Glycan regulation of receptor functions

  • Prof. Naoyuki Taniguchi
• Glycan Involvement in Disease and Disorders
• 31 min
  10. Congenital disorders of N-glycosylation

  • Prof. Harry Schachter
• 44 min
  11. Glycosylation changes during oncogenesis

  • Prof. Michael Pierce
• Innovative Technologies for Glycoscience and Glycomics
• 70 min
  12. Protein-glycan interactions

  • Prof. James Prestegard
• 41 min
  13. Glycobiology: an untapped source of novel drugs

  • Dr. John Magnani
• 59 min
  14. Development of glyco-biomarkers using glycoproteomics technologies

  • Dr. Hisashi Narimatsu
• 40 min
  15. GlycoBioInformatics

  • Dr. René Ranzinger
• Archived Lectures *These may not cover the latest advances in the field
• 46 min
  16. Glycosyltransferases: structures and mechanisms

  • Prof. Monica Palcic
• 50 min
  17. Roles of glycans in yeast cell walls

  • Dr. Peter Lipke

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Recognition of cell surface and soluble glycans
3. Hallmarks of innate and adaptive immunity
4. Innate immune receptors (1)
5. Domain structure of lectin subunits
6. Classification of animal lectins
7. Lectin families
8. C- type lectins
9. The mammalian MBL
10. Direct recognition of microbes / opsonic effect
11. Activation of complement pathways
12. Lectin repertories in self and nonself recognition
13. MsFBP-32 in Morone saxatilis
14. Topology of F-type lectin family (1)
15. Structure of the eel lectin subunit and trimer
16. Interactions of binding sites with ligands
17. Modeling of Le-a and H blood group specificity
18. Topology of F-type lectin family (2)
19. Structure of a binary CRD lectin (MsFBP32) (1)
20. Structure of a binary CRD lectin (MsFBP32) (2)
21. Structure of a binary CRD lectin (MsFBP32) (3)
22. Structure of a binary CRD lectin (MsFBP32) (4)
23. Trimeric CRD displays in F-lectins
24. Sequence variability among eel isolectins
25. Glycan recognition by F-type eel lectin isoforms
26. Topology of F-type lectin family (3)
27. Bindin: F-lectin involved in fertilization
28. Topology of F-type lectin family (4)
29. Discoidin II
30. Self and nonself recognition by F-type lectins
31. Structural and functional diversity of F-lectins
32. Galectins
33. Biological roles of galectins (1)
34. Zebrafish galectin repertoire
35. Drgal1-L2 is strongly expressed in the notochord
36. Skeletal muscle in Drgal1-L2/Drgal1-L4
37. Zebrafish Drgal1-L2
38. Biological roles of galectins (2)
39. Biological roles of galectins (3)
40. Galectins recognize glycans on many pathogens
41. Innate immune receptors (2)
42. Oysters are efficient filter feeders
43. Ultrastructure of Perkinsus sp.
44. Phagocytosis of P. marinus trophozoites
45. A 4-CRD galectin in Crassostrea virginica
46. Properties of rCvGal
47. CvGal location in granulocytes upon attachment
48. Anti-rCvGal antibodies inhibit phagocytosis
49. Subversion of host galectins by parasites
50. Galectins as PRRs
51. Acknowledgments

Topics Covered

• Functional aspects of the glycocalyx in innate immunity and development
• Lectins as recognition and effector factors in innate immunity
• F-type lectins: a novel lectin family
• Structural basis of glycan recognition by F-lectins
• Structural/functional aspects of galectins in development, immune regulation and as pattern recognition receptors
• Subversion of the roles of host galectins by eukaryotic parasites

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Vasta, G. (2012, November 27). Recognition of 'self' and 'non-self' glycans by carbohydrate-binding proteins: structural and functional aspects [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/ZUXZ6984.
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Publication History

• Published on November 27, 2012

Financial Disclosures

• Prof. Gerado Vasta has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.