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Printable Handouts
Navigable Slide Index
- Introduction
- 'Sugar' roles & codes
- 'Sugar' therapeutics
- Drug needs and issues
- Market needs and issues (1)
- Market needs and issues (2)
- Background - Heparosan? (1)
- Background - Heparosan? (2)
- Technology
- Technology - stealth rationale
- Structure of Heparan Sulfate
- Advantages over PEG - bio-inert
- Advantages over PEG - bio-stealthy
- Advantages over PEG - bio-compatible
- Heparosan as a drug delivery vehicle
- Technology overview: PmHS1
- Technology overview - polymer production
- Synthesis of monodisperse Heparosan polymers
- Cargo-coupling chemistries include
- Technology - animal studies
- Technology - half-life study
- Technology - drug stability
- Technology - no accumulation in organs
- Technology - safe degradation
- Technology - cargo coupling
- Technology - cargo coupling via sulhydryls
- Technology - activity of HEP-G-CSF
- Technology - Heparosan toxicology (1)
- Technology - Heparosan toxicology (2)
- Technology - summary
- Value proposition
- Acknowledgements
Topics Covered
- Drug Delivery Vehicles
- Use of stealthy polymers to improve drug cargo pharmacokinetics and fate in the body
- Glycosaminoglycan [GAG] Glycosyltransferases
- Bifunctional synthases polymerize sugar chains
- Chemoenzymatic synthesis; use of enzymes to create defined polymers
Talk Citation
DeAngelis, P.L. (2012, November 27). Use of heparosan polysaccharide to enhance drug delivery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 14, 2024, from https://doi.org/10.69645/GDUJ1252.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Paul L. DeAngelis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Use of heparosan polysaccharide to enhance drug delivery
Published on November 27, 2012
28 min