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1. Introduction
2. Heart failure: the problem
3. Hospitalization and Congestive Heart Failure (CHF)
4. Heart failure hospitalizations
5. The predominant contributor to heart failure costs
6. Mortality in heart failure trials
7. Reasons for increased heart failure
8. Process of heart failure progression
9. Cycle of heart failure progression
10. Medical therapies for heart failure
11. Current treatment of CHF with systolic dysfunction
12. Number of heart transplants worldwide
13. FDA indications for LVAD usage
14. Stem cells in the future treatment of heart failure
15. Stem cells
16. CD34 positive stem cells
17. CD34+ cells differentiation into cardiomyocytes
18. Repair of infarcted myocardium by stem cells
19. Procedure of cells transplantation
20. Improvement in myocardial perfusion
21. Transplantation of progenitor cells
22. Assay of the left ventricular function
23. Evaluation of wall motion
24. Autologous of bone marrow cell transplantation
25. The NOGA myostar injection catheter
26. Injection catheter technique
27. SPECT and electromechanical map analysis
28. Hemodynamic data summary
29. Angiographic and EMM results
30. Infarct remodeling after progenitor cell treatment
31. Ejection fraction and end diastolic volume
32. Initial and follow-up results in endsystolic volumes
33. Evaluation of wall motion
34. Intracoronary autologous bone marrow cell transfer
35. Global LVEF at baseline and 6 months follow-up
36. Subgroup analysis of global LVEF changes
37. Comparison of SMs and CD133+ progenitors
38. LVEF ejection fraction
39. Emax comparison
40. Transendocardial injection of ABMM
41. Number of capillaries
42. Trichrome stain of the heart walls
43. Improved exercise capacity and ischemia
44. MSCs differentiate into endothelial phenotype
45. Ejection fraction at rest and with stress
46. Fibrosis and vascular density comparison
47. Dil staining of the anterior and posterior walls
48. Stem cells in the treatment of heart disease
49. Use of mouse ESC to infarcted sheep myocardium
50. CD133+ cells enhance myocardium function
51. Embryonic versus adult stem cells
52. Conclusions
53. Texas heart institute

Topics Covered

• Heart failure: the problem
• Reasons for increased heart failure
• Current medical treatment of Congestive Heart Failure with systolic dysfunction
• Stem cells in the future treatment of heart failure
• Stem cell reservoirs
• Types of stem cells currently under study

Links

Series:

• Stem Cells and Regenerative Medicine

Categories:

• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Willerson, J. (2007, October 1). Stem cell therapy for the treatment of heart failure [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/242/.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. James Willerson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.