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Printable Handouts
Navigable Slide Index
- Introduction
- Finding key conserved "disease" genes
- Drosophila: good model for human "disease" genes
- VDRC genome wide RNAi in Drosophila
- Using the RNAi library
- Pain behavior in fruit fly
- Finding conserved regulators of nociception
- High temperature is noxious to Drosophila
- Assay for nociception in adult flies
- Drosophila rapidly avoid high temperature
- Painless mutant flies & noxious temperatures
- Nociception screening system in adult fly
- Genome wide nociception screen in adult fly
- Screening data (pathway enrichment)
- Human GWAS for chronic pain after back surgery
- Human GWAS vs. calcium signaling
- Straightjacket (stj) is a novel fly "pain" gene
- stj is found in brain & peripheral sensory neurons
- alpha-2-delta-3 (stj): Drosophila larvae "pain" gene
- alpha-2-delta-3 mutant larvae
- Generation of alpha-2-delta-3 KO mice
- KO mice show delayed nociception responses
- alpha-2-delta-3 KO mice basic phenotype
- The pain circuit
- Problem - no difference in a tail flick assay
- alpha-2-delta-3 may act in the brain
- KO mice: possible altered pain processing in brain
- fMRI setup
- alpha-2-delta-3: thalamus to SSC transmission
- Problem - there is overall normal total brain activity
- Loss of alpha-2-delta-3
- alpha-2-delta-3 (stj): an acute & chronic pain gene
- Conclusions
- Acknowledgements
Topics Covered
- Finding key conserved pain genes in drosophila as a model for human genes
- Finding conserved regulators of nociception
- Assay for nociception in adult flies
- Painless mutant flies & noxious temperatures
- Genome wide nociception screen in adult fly
- Human GWAS for chronic pain gene
- Alpha-2-delta-3 (Straightjacket = stj) as a novel acute & chronic pain gene and the effect on its manipulation in mice and flies
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Talk Citation
Neely, G. (2012, October 31). Nociception and alpha2delta3 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/MZJQ2815.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Greg Neely has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.