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1. Introduction
2. Talk outline
3. Neurons are unique cells
4. Calcium signaling pathways in neurons
5. Calcium signaling in neurons
6. The ER is distributed throughout the neuron
7. Calcium induced calcium release
8. Visualizing the CICR
9. Calcium signaling pathways in neurons
10. Excess calcium leads to cellular pathology
11. How ER calcium signaling is linked to AD
12. Alzheimer's disease
13. Presenilin mutations
14. Support for the calcium hypothesis of AD
15. Transgenic AD mice
16. PS1KI vs. non-tg ER calcium responses
17. NonTg vs. AD ER calcium responses
18. Three possible mechanisms
19. The RyR is upregulated in AD mice at early ages
20. RyR-evoked calcium release
21. Dysregulated ER calcium affects neurophysiology
22. Effects of altered ER calcium dysregulation
23. AD neuron - higher postsynaptic calcium response
24. Aberrant CICR in AD mice generated by NMDAR
25. Sensitized CICR via the RyR
26. Effects of dysregulated ER calcium signaling
27. Baseline and presynaptic plasticity mechanisms
28. Blocking the RyR affects LTP expression
29. Blocking the RyR affects LTD expression
30. How enhanced calcium may 'enable' AD? (1)
31. Complex dynamic interactions - a summary
32. Beta amyloid peptides and plaque deposition
33. Hyperphosphorylated tau and calcium
34. ApoE4 alleles
35. Apoptosis and toxicity
36. How enhanced calcium may 'enable' AD? (2)

Topics Covered

• Neuronal Ca2+ signaling pathways and associated functions/dysfunctions
• Alzheimer's disease, features and mechanisms
• Alzheimer's disease and calcium signaling deficits, sources, specific effects on synaptic transmission, early and late contributions to pathology
• How dysregulated calcium can feed into AD pathology

Links

Series:

• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Stutzmann, G. (2012, October 31). Ca2+ signaling alterations in Alzheimer's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ZQVI1565.
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Publication History

• Published on October 31, 2012

Financial Disclosures

• Dr. Grace Stutzmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.