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1. Introduction
2. Alzheimer's disease (1)
3. Alzheimer's disease (2)
4. Outline of talk
5. Apolipoprotein E (ApoE)
6. ApoE genotype frequency in the population
7. ApoE4 decreases the age of onset of AD
8. ApoE4 dependent brain pathology in AD (1)
9. Isoform effects of ApoE4 on amyloid deposition
10. ApoE4 dependent brain pathology in AD (2)
11. Brain inflammation in ApoE4 positive patients
12. ApoE4 dependent brain pathology in AD (3)
13. ApoE4 role in neuronal remodeling & brain trauma
14. ApoE4 dependent brain pathology in AD (4)
15. ApoE4 & amyloid deposition on blood vessels
16. ApoE4 dependent brain pathology in AD (5)
17. The effects of ApoE4 start early
18. ApoE4 is a risk factor for other diseases
19. Age related macular degeneration and ApoE4
20. Pathological effects of ApoE4 - mechanisms
21. Phenotypic effects of ApoE4 in transgenic mice
22. Molecular mechanisms: lipid metabolism
23. ApoE and brain cholesterol
24. ApoE4 lipid cross talk: experimental design
25. Effects of ApoE4 diets & environmental stimulation
26. Effects of DHA and cholesterol on behavior
27. ApoE4 mechanisms (1)
28. Molecular mechanisms: amyloid cascade
29. Effects of human ApoE4 isoforms on brain A-beta
30. ApoE4 mechanisms (2)
31. In vivo activation of the amyloid cascade
32. ApoE4 driven accumulation of intracellular A-beta
33. Neuronal loss following accumulation of A-beta
34. Intracellular pathology and A-beta in ApoE4 mice
35. A-beta oligomerization (1)
36. A-beta oligomerization (2)
37. ApoE4-induced A-beta mediated neurotoxicity
38. ApoE4 mechanisms (3)
39. How do ApoE and A-beta interact
40. Molecular mechanisms: ApoE receptors
41. LDL receptor family members
42. ApoER2 and NMDA receptors
43. ApoER2 and NMDA receptors: ApoE4 toxicity
44. ApoE4 driven accumulation of A-beta by LRP
45. ApoE4 mechanisms (4)
46. Molecular mechanisms: ApoE4 catabolism
47. Conformation and catabolism of ApoE3 and ApoE4
48. Consequence of ApoE4 fragmentation
49. ApoE4 mechanisms (5)
50. Neurodegeneration, Vascular pathology
51. ApoE4 directed therapy
52. ApoE4: loss of function vs. gain of toxic function
53. A-beta accumulation by ApoE4: gain of function
54. ApoE4 related therapeutic approaches
55. ApoE4 affects the efficacy of clinical trials
56. Summary of talk
57. Acknowledgements

Topics Covered

• ApoE4 the most prevalent genetic risk factor of Alzheimer's disease
• The apoE4 molecule
• The associated brain pathology in man
• The mechanisms underlying the pathological effects of apoE4
• The role of lipids in mediating the effects of apoE4
• The role of Amyloid-beta in mediating the effects of apoE4
• ApoE4 receptors
• ApoE4 catabolism
• ApoE4 targeted therapeutic approaches
• Therapeutic approaches based on the apoE4 molecule
• Therapeutic approaches based on preventing pathologic interactions with other systems

Links

Series:

• Alzheimer's Disease

Categories:

• Biochemistry
• Clinical Practice
• Genetics & Epigenetics
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Michaelson, D. (2012, October 2). ApoE4 - the most prevalent genetic risk factor for Alzheimer's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 17, 2024, from https://doi.org/10.69645/MZUJ6576.
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Publication History

• Published on October 2, 2012

Financial Disclosures

• Prof. Daniel Michaelson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.