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1. Introduction
2. Pathophysiology of COPD & Emphysema
3. Lung with COPD
4. Carl-Bertil Laurell
5. Alpha 1 antitrypsin deficiency
6. Antitrypsin deficiency and emphysema lungs 3D
7. The alpha 1 antitrypsin protein
8. Alpha 1 antitrypsin and elastase
9. The elastase
10. Elastase and emphysema
11. Elastase and other symptoms
12. Beat frequency and elastase
13. Effects of neutrophil elastase
14. Augmentation in AATD
15. Augmentation therapy
16. Anti inflammatory effects
17. Testing emphysema progression
18. Location of emphysema
19. Emphysema in patients without AATD
20. Emphysema with normal lung function
21. Alternative approach for assessing emphysema
22. The complexity of neutrophil biology
23. An inflammatory cell in connective tissue (1)
24. An inflammatory cell in connective tissue (2)
25. Processes of neutrophil movement
26. Cell movement towards signal
27. Elastase concentration in azurophil granules
28. Elastase concentration change
29. Quantum proteolytic events of neutrophils
30. Destructive potential of neutrophils
31. Chemotaxis of neutrophils
32. Neutrophil adherence and migration
33. Neutrophils and COPD
34. Monitoring neutrophil elastase activity in vivo
35. Neutrophil mechanism
36. Fibrinogen cleavage point for elastase
37. A-alpha360 and elastase inhibitors
38. COPD and A-alpha360
39. PET scanning and FDG labeling
40. Role of proteinases in emphysema
41. The other neutrophil serine proteinases
42. The smoking mouse
43. Alveoli in smokers vs. non smokers
44. MMP-12 KO mouse
45. MMP-12 KO and neutrophils
46. Neutrophil elastase KO mouse
47. Enzyme interactions
48. TNF alpha and MMP-12 KO mice
49. TNF and inflammation
50. No connective tissue damage
51. A different pathway
52. A short summary
53. Effects of TNF alpha polymorphisms
54. The roles of MMPs
55. The process diagram
56. Summary

Topics Covered

• Pathophysiology of COPD and Emphysema
• Carl-Bertil Laurell
• Alpha 1 antitrypsin deficiency
• Effects of neutrophil elastase
• Augmentation therapy
• Anti inflammatory effects
• Testing emphysema progression
• Emphysema with normal lung function
• Alternative approach for assessing emphysema
• The complexity of neutrophil biology
• Processes of neutrophil movement
• Elastase concentration change
• Quantum proteolytic events of neutrophils
• Destructive potential of neutrophils
• Chemotaxis
• Neutrophils and COPD
• Monitoring neutrophil elastase activity in vivo
• Elastase inhibitors
• Role of proteinases in emphysema
• The other neutrophil serine proteinases
• The smoking mouse
• Alveoli in smokers vs. non smokers
• Effects of TNF alpha polymorphisms
• The roles of MMPs

Links

Series:

• Advances in Chronic Obstructive Pulmonary Disease (COPD)

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on September 13, 2012

Financial Disclosures

• Prof. Robert Stockley has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.