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• 25 min
  1. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  2. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  3. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  4. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  5. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  6. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  7. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  8. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  9. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  10. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  11. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  12. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  13. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  14. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  16. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

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  17. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  18. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  19. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  20. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  21. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  22. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  23. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  24. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  25. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  26. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  27. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Cell-derived antibody concept
3. Serum protein electrophoresis (SPEP)
4. Structure of IgG molecule
5. Functional sites on the IgG molecule
6. IgM
7. Selected functions of Ig classes
8. Terminology
9. Major features of Fc-gamma receptors
10. Effector function by Fc-gamma receptors
11. Fc-gamma receptor signaling
12. Phosphorylated ITAMs
13. Phosphatidylinositol 3-kinase (PI 3-kinase)
14. Fc-gamma-R-mediated phagocytosis
15. ITAM inhibitory signaling
16. Fc-gamma-RIIB: an inhibitory Fc-gamma receptor
17. SHIP, an inositol 5' phosphatase
18. Fc-gamma-RIIB co-recruitment
19. Activating BCR and inhibitory Fc-gamma-RIIB
20. FcRn
21. Fc receptors: hypersensitivity and autoimmunity
22. Fc-epsilon-RI early signal transduction events
23. The Arthus reaction
24. Requirement of activating Fc-gamma-Rs (1)
25. Requirement of activating Fc-gamma-Rs (2)
26. Fc-gamma-RIIa alleles
27. Fc-gamma-RIIa
28. Fc-gamma-RIIb
29. Fc-gamma receptors hypothesis
30. Summary: Fc receptors
31. Biology of complement
32. Complement: early history
33. Recognized functions of complement
34. What is complement?
35. How complement contributes to host defense
36. Complement activation in host defense
37. The first step in complement cascade initiation
38. Proteolysis catalyzes complement activation
39. The core complement proteins
40. C1q
41. The classical pathway of complement activation
42. Steps in activation of C3
43. Similarities between C1 complex and MBL-MASP
44. Complement activation in antibodies absence
45. Complement activation - alternative pathway
46. All roads lead to Rome
47. C5a
48. Big MAC attack
49. Receptors for various complement components
50. CRIg
51. C3b and CR1
52. Clearance of immune complexes
53. Proteolytic fragments of the compliment C3
54. Positive and negative regulation of the BCR
55. Complement regulatory protein CD46 defect
56. Local production of complement proteins
57. Maximal co-stimulation requires complement
58. Complement regulatory proteins
59. Disposal of apoptotic debris
60. Defective apoptotic cell clearance consequences
61. Inherited complement deficiencies
62. Leukocyte adhesion deficiency (LAD)
63. Hereditary angioneurotic edema
64. Paroxysmal nocturnal hemoglobinuria
65. Summary: complement

Topics Covered

• Biology of Fc receptors
• Activating and inhibitory functions of Fc receptors
• Fc receptors in disease
• Biology of complement proteins
• Biology of complement receptors
• Complement receptors in disease

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on September 10, 2012

Financial Disclosures

• Prof. Steven Greenberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.