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Printable Handouts
Navigable Slide Index
- Introduction
- Oxidants and antioxidant balance in the lungs
- Oxidants and antioxidants in the lungs
- Oxidative stress in COPD overview (1)
- Measurements of oxidative stress
- Synthesis of nitric oxide (NO)
- Nitrosative stress in COPD
- Mechanisms of membrane lipid peroxidation
- 4-hydroxy-2-nonenal-adducts in COPD
- Does oxidative stress occur in COPD?
- Smoke induced emphysema in Nrf2 KO mice
- Decline in NRF2-regulated antioxidants in COPD
- Nrf2 and oxidative stress relationship in COPD
- Regulation of NRF2 in COPD patients
- NRF2 targeting with CDDO
- What are the consequences of OS in COPD?
- Model of histone acetylation and deacetylation
- Effect of smoking and COPD on HDAC2
- Nitration and HDAC2 activity
- Smoke induced oxidative stress effects
- Emphysema: apoptosis
- Apoptosis and VEGF in emphysematous lungs
- Apoptosis and oxidative stress
- Decreased proteins in lungs of COPD patients
- Molecular alterations in COPD lungs
- Molecular alterations in COPD muscles
- Protease / antiprotease
- NRF2 way of protection against emphysema
- NAC attenuates elastase-induced emphysema
- Accelerated aging
- Free radical theory of aging or senescence
- Accelerated aging in COPD
- SIRT-1 is decreased in the lungs in COPD
- SMP-30 and age-associated deterioration
- Effects of decreased SIRT1
- Pathogenic triad of COPD
- Mucus hypersecretion
- Oxidants and mucin production
- Airway remodelling
- A link between oxidative injury and fibrosclerosis
- Immune modulation
- The nature of small-airway obstruction in COPD
- HO1 prevents smoke induced B-cell infiltrates
- Oxidative stress role in auto-immune response
- Oxidative stress in COPD: summary
Topics Covered
- The involvement of oxidative stress in the pathogenic mechanisms of COPD
- Downregulation of antioxidant defenses
- Enhanced inflammation
- Apoptosis
- Protease/antiprotease imbalance
- Accelerated aging
- Immunemodulation
- Potential for targeted therapy
Links
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Talk Citation
MacNee, W. (2012, July 31). Oxidative stress in COPD [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 5, 2024, from https://doi.org/10.69645/KZPU5402.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. William MacNee has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.