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1. Introduction
2. Outline
3. FEV1 decline and disability
4. Decline of FEV1 in COPD
5. Symptomatic COPD: natural history?
6. New evidence
7. Physical activity in COPD
8. Health-related quality of life scores
9. A question arises
10. Inflammation in the early stages of COPD
11. Small-airway obstruction and emphysema
12. Pathophysiology of mild COPD
13. Mechanisms of air trapping (1)
14. Cross-sectional study
15. Natural history of lung hyperinflation in COPD
16. COPD challenge test
17. Cardiopulmonary exercise testing
18. Exertional dyspnea intensity
19. Exercise responses in symptomatic COPD
20. Ventilatory response to exercise
21. Ventilation-perfusion imbalance in COPD
22. Operating lung volumes during exercise
23. The importance of dynamic lung hyperinflation
24. Respiratory mechanical measurements
25. Esophageal pressure and flow tracings
26. Respiratory muscle pressures during exercise (1)
27. The continuum of COPD
28. Respiratory muscle pressures during exercise (2)
29. Dyspnea with increasing COPD severity
30. Intensity and quality of dyspnea
31. Progressive neuromechanical dissociation
32. Operating lung volumes during exercise (1)
33. Sensory-mechanical relations during exercise (1)
34. Sensory-mechanical relations during exercise (2)
35. Respiratory mechanics at the limits of tolerance
36. Evolution of dyspnea during exercise in COPD
37. Neuromechanical coupling and dissociation
38. Conclusions (1)
39. Conclusions (2)
40. Improving dyspnea and activity restriction
41. Pharmacological volume reduction
42. Lung hyperinflation and its reversibility
43. Bronchodilator responsiveness
44. Mechanisms of air trapping (2)
45. Pulmonary function post ipratropium bromide
46. Impact of acute anticholinergic therapy
47. Mechanical measurements during exercise
48. Operating lung volumes during exercise (2)
49. Effects of lung volume deflation
50. IC response to long-acting bronchodilators
51. Improvements in respiratory mechanics
52. Responses to bronchodilators in COPD
53. Conclusions (3)
54. Clinical course of COPD (1)
55. Clinical course of COPD (2)

Topics Covered

• Evolution of respiratory impairments from mild to sever COPD
• Progression of the symptoms of COPD: dyspnea and exercise impairment
• Mechanism s of progression
• Optimizing respiratory mechanics

Links

Series:

• Advances in Chronic Obstructive Pulmonary Disease (COPD)

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

O'Donnell, D. (2012, July 31). The continuum of COPD: a physiological perspective [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/2362/.
Export Citation (RIS)

Publication History

• Published on July 31, 2012

Financial Disclosures

• Prof. Denis O'Donnell has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.