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1. Introduction
2. Disclosure of interest
3. Why phenotype / subgroup? (1)
4. Why phenotype / subgroup? (2)
5. Phenotypes - one definition
6. The "frequent exacerbator"?
7. Eclipse study
8. Exacerbations frequency and severity
9. Multinomial regression
10. Eclipse study virtue
11. Stability of the exacerbator phenotype
12. Frequent exacerbator clinical review
13. There are no certainties
14. COPD equation
15. Venn diagram
16. COPD - phenotypes
17. First case of alpha1-antitrypsin deficiency 1963
18. Severe emphysema X-ray image
19. Severe emphysema CT scan
20. MicroCT of the lung study
21. Emphysema and small airways
22. Patients with COPD and asthma
23. Asthma and FEV1 decline
24. Chronic bronchitis
25. Mucus hypersecretion, and decline in FEV1
26. Predictive value of chronic bronchitis
27. COPD archetype
28. Important phenotypes in COPD
29. FEV1 decline, disease progression and severity
30. COPD activity
31. FEV1 decline by stage
32. A biomarker for disease activity in COPD
33. COPD lung function decline variety (1)
34. COPD lung function decline variety (2)
35. COPD biomarkers
36. Novel COPD phenotypes
37. How many phenotypes are there?
38. Conclusions

Topics Covered

• COPD
• More than one disease
• Definition of phenotypes
• Consideration of subgroups of COPD
• Traditional subgroupings
• Recently defined subgroupings
• What is the future of COPD?

Links

Series:

• Advances in Chronic Obstructive Pulmonary Disease (COPD)

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on July 31, 2012
• Archived on February 25, 2021

Financial Disclosures

• Prof. Jørgen Vestbo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.