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25 min
1. Mononuclear phagocytes - origins, fates and functions- Prof. Steffen Jung
-
39 min
2. Transcription factors in macrophage differentiation- Dr. Michael Sieweke
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44 min
3. Fetal macrophages- Prof. Paul Martin
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44 min
4. The alveolar macrophage- Dr. Ronald G. Crystal
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35 min
5. Airway macrophages in health and disease- Prof. Tracy Hussell
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65 min
6. Intestinal macrophages - heterogeneity, origins and functions- Prof. Allan Mowat
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27 min
7. Osteoclasts: what do they do and how do they do it?- Prof. Steven L. Teitelbaum
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51 min
8. The biology of Fc receptors and complement receptors- Prof. Steven Greenberg
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71 min
-
38 min
10. Tumour-associated macrophages- Prof. Michele De Palma
- Dr. Mario Squadrito
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42 min
11. The recognition of pathogens by C-type lectins- Prof. Gordon D. Brown
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34 min
12. Macrophage phagocytosis- Prof. Joel Swanson
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30 min
13. Macrophage CD36 and atherosclerosis- Dr. Maria Febbraio
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31 min
14. Toll-Like receptor signaling and the innate immune response- Dr. Kate Fitzgerald
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43 min
15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria- Prof. Ricardo Gazzinelli
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34 min
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69 min
17. Triggering receptors expressed on myeloid cells (TREM)- Dr. Daniel W. McVicar
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60 min
18. Influence of eicosanoid lipid mediators on macrophage innate immune functions- Prof. Marc Peters-Golden
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47 min
19. Macrophage paired receptor interactions- Prof. Neil Barclay
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45 min
20. Macrophage heterogeneity in atherosclerosis regression- Prof. Edward Fisher
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35 min
21. Gaucher disease: from lysosomal storage to immunopathology- Prof. Johannes M.F.G. Aerts
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26 min
22. Macrophage in asthma- Prof. Douglas Robinson
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51 min
23. The macrophage mannose receptor- Dr. Luisa Martinez-Pomares
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41 min
24. Myeloid-derived suppressor cells in cancer- Prof. Dmitry Gabrilovich
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29 min
25. EGF-TM7 receptors- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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37 min
26. Macrophages in helminth infection- Prof. Judith Allen
- Archived Lectures *These may not cover the latest advances in the field
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49 min
27. Immunosuppressive mechanisms in myeloid cells- Prof. Dmitry Gabrilovich
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- MR structure and function
- Domains and binding properties of MR
- MR is an endocytic receptor
- MR is a receptor for collagen
- The MR family
- MR expression
- Regulation of MR expression in macrophages
- MR conformation
- MR conformation - bended conformation
- MR-glycosylation
- MR binding properties and glycosylation
- MR and phagocytosis
- MR and cellular activation
- MR is shed
- Fungi up-regulate MR shedding
- Beta-glucan enhances MR shedding
- Selected expression of CR-ligands
- The "sMR-mediated delivery pathway"
- Data in support of sMR-mediated Ag transport
- Current hypothesis
- CR-ligands in rat spleen
- CR-ligands in human spleen
- Structure and function: conclusions
- MR and antigen presentation
- MR and self-recognition
- MR and antigen presentation to T cells
- MR expression in secondary lymphoid organs
- MR expression in lymph nodes
- MR in CD11c high DC
- MR ligands do not target T cell areas
- MR expression is highly regulated
- Targeting of anti-MR and LPS
- MR ligands elicit enhanced humoral responses
- MR ligands in peripheral tissues
- MR and antigen presentation to T cells
- MR and cross-presentation
- MR and disease
- Two MR-deficient strains
- MR and host defence
- MR and allergy
- MR contributes to allergen uptake
- MR deficiency reduces Th2 polarisation
- IDO as the potential effector molecule
- Increased IDO activity in MR-deficient DC
- Inhibiting IDO restores Th2 polarisation
- Mimicking IDO reduces Th2 polarisation
- Inhibition of IDO - recap
- MR deficiency reverse effect
- IDO metabolite treatment
- MR contributes to Fel d 1 allergenicity in vivo
- MR variants and asthma susceptibility
- MR and allergy: conclusions
- MR as a promoter of Th2 polarisation
- MR and cellular responses in LN draining site
- MR and schistosomiasis: conclusions
- MR and glomerulonephritis (NTN model)
- Immuno-complexes deposition in kidneys
- MR deficiency protects from renal injury
- Interplay between MR and Fc receptors
- MR promotes FcR-function
- MR deficiency and mesangial cell proliferation
- MR-deficient cells - less pro-inflammation
- MR in murine NTN: conclusions
- MR and cancer
- MR is expressed in tumours
- MR promotes anti-inflammatory response
- MR promotes tumour metastasis
- miR-511-3p modulates genetic programs
- Regulation of cellular activation
- Issues raised by the existence of miR-511-3p
- MR and cancer: conclusions
- Summary
- Acknowledgements
- Acknowledgements - research funding
- Thank you for listening
- References (1)
- References (2)
- References (3)
- References (4)
- References (5)
Topics Covered
- The mannose receptor (MR)
- Structure and function
- Domains and binding properties of MR
- The MR family
- MR expression
- MR as an endocytic receptor
- MR conformation and glycosylation
- MR and phagocytosis
- MR and cellular activation
- MR shedding
- Ligands for the cysteine-rich domain of MR
- MR and antigen presentation
- MR and self-recognition
- MR and activation of T cells
- MR and disease
- Role of MR in host defence
- MR and allergy
- MR and glomerulonephritis
- MR and cancer
Links
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Talk Citation
Martinez-Pomares, L. (2012, June 11). The macrophage mannose receptor [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/HOFF6528.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Luisa Martinez-Pomares has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The macrophage mannose receptor
Published on June 11, 2012
51 min
