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1. Introduction
2. Asthma: what is it?
3. Asthma: who gets it?
4. Asthma: why study it?
5. Asthma: immunopathology
6. Asthma: similar or different?
7. Asthma: lack of regulation?
8. Asthma: abnormal epithelium?
9. Airway macrophages in asthma
10. Monocytes and macrophages
11. Monocytes
12. Macrophage activation pathways
13. Different macrophage activation pathways
14. Macrophages in the lung
15. Macrophages in asthma (1)
16. Antigen presenting cell function
17. Alternatively activated macrophages in asthma
18. Macrophages in asthma (2)
19. IL-13 and airway macrophages in asthma
20. IL-13 in asthma
21. Airway remodelling and macrophages: osteopontin
22. Regulation of asthma pathology by macrophages
23. Summary

Topics Covered

• Contributing factors to asthma include abnormal epithelium, predominant Th2 cytokines, and inappropriate repair leading to airway remodeling
• Alternative activation of macrophages (via IL-4 and IL-13) leads to chitinase production
• Interstitial macrophages may have regulatory role (via IL-10)
• IL-13 may be a key cytokine in activation of airway macrophages
• IL-13 amplifies features of asthma such as airway hyperresponsiveness and mucus production

Links

Series:

• Advances in Asthma
• Macrophage Heterogeneity and Function

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Prof. Douglas Robinson, Consultant: Roche