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Printable Handouts

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Navigable Slide Index

1. Introduction
2. Regression: from bad to better?
3. Mouse model of regression (1)
4. Absence of macrophages after regression
5. Mouse model of regression (2)
6. Rapid exit of monocyte-derived cells
7. First hint of macrophage heterogeneity
8. Heterogeneity of cell types in arterial lesions
9. Example of LCM of macrophage foam cells
10. Blocking the CCR7 pathway blocks regression
11. Summary of part 1
12. Lipoprotein changes from apoE-/- to WT mice
13. HDL and vascular protection
14. Model to test selective normalization of HDL-C
15. Normalization of HDL-C promotes regression
16. Regression is impaired
17. HDL modulates CCR7 levels
18. Molecular mechanism for CCR7 regulation
19. Evidence for SRE-activation in vivo
20. Summary of part 2
21. Part 3: changes in macrophage polarization
22. Classification of macrophages in tissues
23. HDL regulates the inflammatory state (1)
24. HDL regulates the inflammatory state (2)
25. HDL enriches CD68+ cells in M2 markers (1)
26. HDL enriches CD68+ cells in M2 markers (2)
27. Are the changes model dependent?
28. MiR-33 negatively regulates ABCA1 expression
29. Predicted effects of blocking miR-33
30. miR-33 in LDLr-/- mice regulates HDL Levels
31. Less inflammation in plaque macrophages
32. Some models of macrophage "plasticity"
33. Summary of part 3
34. Overall summary (1)
35. Overall summary (2)
36. Acknowledgements

Topics Covered

• Novel research tools
• Developing mouse models to study atherosclerosis regression
• Developing the tools to analyze macrophage trafficking and molecular phenotypes in vivo
• The regression of atherosclerosis by HDL due to its effects on the quantity and phenotype of macrophages in plaques
• Macrophage polarization
• Plasticity during atherosclerosis regression
• Models for the enrichment in cells in the M2 state

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 11, 2012

Financial Disclosures

• Prof. Edward Fisher, Consultant: Merck; Speaker’s Bureau: Merck; Grant/Research Support (Principal Investigator): Merck