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  16. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
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Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. KARAP/DAP12
4. Inhibitory and activating NKR
5. Activating KIRs - paper
6. DAP12 - papers
7. Inhibitory and activating NKR - mechanisms
8. ITAM-bearing transducing polypeptide
9. Proteins with ITAM
10. KIR signaling pathways
11. ITAM in NK cells and macrophages
12. KARAP/DAP12 associated receptors
13. DAP12 association with ITAM
14. DAP12 role in osteoclastogenesis
15. PLOSL/Nasu-Hakola
16. ITAM-bearing subunits in osteoclastogenesis
17. Integration of RANK and ITAM signaling
18. DAP12 role in giant cell formation
19. Spontaneous fatal inflammatory syndrome (1)
20. Spontaneous fatal inflammatory syndrome (2)
21. Multinucleated giant cells
22. Quantitation of macrophage fusion
23. Impaired macrophage fusion in vitro
24. DAP12 knock down reduces macrophage fusion
25. DAP12 overexpression enhances fusion
26. TREM-2 and Syk as examples
27. The TREM2:DAP12:Syk signaling pathway
28. Reduced expression of fusion mediators
29. Macrophages programmed into a fusogenic state
30. Impaired macrophage fusion in vivo
31. Pathways of granuloma formation
32. Programming into a fusion-competent state
33. DAP12 cross-talks with other signaling pathways
34. Integrated signaling by ITAM and TLRs
35. ITAM and cytokine Jak-STAT signaling
36. Activating/inhibitory pathways initiated by DAP12
37. Indirect inhibition of TLR
38. Receptor isotypy
39. DAP12 and DAP10
40. DAP12, DAP10 interaction with receptors
41. Immune response adaptation
42. Isotypy via differential adaptor association
43. Summary

Topics Covered

• KARAP/DAP12/Tyrobp: Three names and a multiplicity of biological functions in cellular interactions
• Signal transduction
• ITAM
• Myeloid cells
• Osteoclasts
• Bone remodelling
• Giant cells formation
• Inflammation
• Natural killer cells

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Vivier, E. (2012, May 8). KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/NSYU5659.
Export Citation (RIS)

Publication History

• Published on May 8, 2012

Financial Disclosures

• Prof. Eric Vivier has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.