• View the Talks
• 25 min
  1. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  2. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  3. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  4. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  5. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  6. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  7. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  8. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  9. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  10. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  11. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  12. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  13. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  14. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  16. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  17. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  18. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  19. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  20. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  21. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  22. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  23. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  24. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  25. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  26. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  27. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Why we need innate immunity
3. Innate immune recognition of microbial products
4. Gram-negative lipopolysaccharides (1)
5. Gram-negative lipopolysaccharides (2)
6. How LPS is recognized
7. Cloning of Drosophila Toll
8. Leucine-rich repeats (LLR) in TLRs
9. The TLR/IL-1R superfamily
10. LPS hypo-responsive C3H/HeJ mice
11. Ligand induced activation of TLR3
12. Pattern recognition, MD-2
13. MD-2 has a "pocket" for LPS
14. The TLR4-MD-2-LPS complex
15. All infectious diseases involve TLRs
16. Localization of TLRs
17. Significance of endosomal localization of TLR9
18. Heterologous expression of TLR4
19. Generic model of signaling by all PRRs
20. LPS triggers activation of NFkB-driven cytokines
21. Studying pathway activation in MyD88-/- mice
22. MyD88 independent pathway
23. MyD88 dependent vs. independent pathways
24. TLRs signal through TIR domain adapter molecules
25. TLR signaling: schematic representation
26. LPS triggers two major signaling pathways
27. TLR4 and TLR3 signaling pathways
28. Adaptor molecule localization
29. LPS activation of TLR4: model (1)
30. Post translational modification of TRAM
31. TRAM mutant
32. LPS activation of TLR4: model (2)
33. Sorting vs. Signaling adapters
34. Delivery of TLR4 to phagosomes
35. Signaling downstream of TRIF/TRAM
36. Phosphorylation induced activation of IRF-3
37. IKK-related kinase TBK1
38. Control of TLR signaling by soluble TLRs
39. Transmembrane & intracellular regulators of TLR

Topics Covered

• TLR signaling and innate immune response: Innate Immunity
• Recognition of pathogen associated molecular patterns (PAMPs) such as LPS
• Pattern recognition receptors (eg. TLRs) recognize microbial products
• Effector cytokines driven by PRR signaling
• Signaling intermediates employed downstream of TLRs
• Counterregulation of TLR signaling as a mechanism to prevent excessive inflammation

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Dr. Kate Fitzgerald has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.