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1. Introduction
2. Why we need innate immunity
3. Innate immune recognition of microbial products
4. Gram-negative lipopolysaccharides (1)
5. Gram-negative lipopolysaccharides (2)
6. How LPS is recognized
7. Cloning of Drosophila Toll
8. Leucine-rich repeats (LLR) in TLRs
9. The TLR/IL-1R superfamily
10. LPS hypo-responsive C3H/HeJ mice
11. Ligand induced activation of TLR3
12. Pattern recognition, MD-2
13. MD-2 has a "pocket" for LPS
14. The TLR4-MD-2-LPS complex
15. All infectious diseases involve TLRs
16. Localization of TLRs
17. Significance of endosomal localization of TLR9
18. Heterologous expression of TLR4
19. Generic model of signaling by all PRRs
20. LPS triggers activation of NFkB-driven cytokines
21. Studying pathway activation in MyD88-/- mice
22. MyD88 independent pathway
23. MyD88 dependent vs. independent pathways
24. TLRs signal through TIR domain adapter molecules
25. TLR signaling: schematic representation
26. LPS triggers two major signaling pathways
27. TLR4 and TLR3 signaling pathways
28. Adaptor molecule localization
29. LPS activation of TLR4: model (1)
30. Post translational modification of TRAM
31. TRAM mutant
32. LPS activation of TLR4: model (2)
33. Sorting vs. Signaling adapters
34. Delivery of TLR4 to phagosomes
35. Signaling downstream of TRIF/TRAM
36. Phosphorylation induced activation of IRF-3
37. IKK-related kinase TBK1
38. Control of TLR signaling by soluble TLRs
39. Transmembrane & intracellular regulators of TLR

Topics Covered

• TLR signaling and innate immune response: Innate Immunity
• Recognition of pathogen associated molecular patterns (PAMPs) such as LPS
• Pattern recognition receptors (eg. TLRs) recognize microbial products
• Effector cytokines driven by PRR signaling
• Signaling intermediates employed downstream of TLRs
• Counterregulation of TLR signaling as a mechanism to prevent excessive inflammation

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Fitzgerald, K. (2012, May 8). Toll-Like receptor signaling and the innate immune response [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/CQTC6877.
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Publication History

• Published on May 8, 2012

Financial Disclosures

• Dr. Kate Fitzgerald has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.