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1. Intro slide
2. Human prion diseases - classification
3. Prion disease - animals
4. Outline
5. Prion protein (PrP) - hamster
6. Prion protein - normal processing
7. Prion protein - membrane association
8. Normal Prp and PrP(C) 3D-structure
9. Proposed biological functions of normal PrP
10. Pathogenesis of prion diseases
11. PrP(C) and PrP(Sc)/PrP(res) 3D-structure
12. Possible mechanism of PrP propagation
13. PrP propagation in familial forms
14. PrP propagation in acquired form
15. Pathogenetic hypotheses
16. Prion protein (PrP) - hamster
17. Immunoblotting of PrP(C) and PrP(Sc)
18. Immunoblot analysis (case 1 brain biopsy)
19. Human prion diseases - inherited
20. Human PrP - pathogenic mutations/polymorphisms
21. Human prion diseases - sporadic
22. Variants of sCJD
23. Human PrP gene - codon 129 polymorphism
24. Immunoblotting of PrP(C) and PrP(Sc)
25. Classification of sporadic CJD - 300 subjects
26. Codon 129 alleles and PrP(Sc) types
27. Classification of sporadic prion diseases
28. Microscopic view of cerebral cortex
29. sCJDMV2 - only sCJD subtype with kuru plaques
30. PrP immunostain - cerebral cortex
31. 14-3-3 test sensitivity and PrP(Sc) type/phenotype
32. Human prion diseases - acquired by infection
33. Iatrogenic CJDs
34. BSE and vCJD epidemics
35. Variant CJD (1)
36. Variant CJD (2)
37. Variant CJD - "fluorid plaque"
38. PrP immunostain - variant/sporadic CJD
39. The problem of CWD in the USA
40. Prion diseases - treatment
41. Prion research collaborators

Topics Covered

• Normal function of prion protein
• Prion diseases
• Mechanism of propagation of PrP
• Propagation in acquired and familial forms
• Pathogenic hypothesis
• Human pathogenic mutation and polymorphisms
• Laboratory methods
• Epidemiology
• Sporadic prion diseases
• New variant CJD
• Treatment of prion disease

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Pierluigi Gambetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.