Interleukin-17: from clone to clinic
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2. Transcription factors in macrophage differentiation- Dr. Michael Sieweke
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3. Fetal macrophages- Prof. Paul Martin
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4. The alveolar macrophage- Dr. Ronald G. Crystal
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5. Airway macrophages in health and disease- Prof. Tracy Hussell
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6. Intestinal macrophages - heterogeneity, origins and functions- Prof. Allan Mowat
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7. Osteoclasts: what do they do and how do they do it?- Prof. Steven L. Teitelbaum
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51 min
8. The biology of Fc receptors and complement receptors- Prof. Steven Greenberg
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10. Tumour-associated macrophages- Prof. Michele De Palma
- Dr. Mario Squadrito
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11. The recognition of pathogens by C-type lectins- Prof. Gordon D. Brown
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12. Macrophage phagocytosis- Prof. Joel Swanson
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13. Macrophage CD36 and atherosclerosis- Dr. Maria Febbraio
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18. Influence of eicosanoid lipid mediators on macrophage innate immune functions- Prof. Marc Peters-Golden
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19. Macrophage paired receptor interactions- Prof. Neil Barclay
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20. Macrophage heterogeneity in atherosclerosis regression- Prof. Edward Fisher
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22. Macrophage in asthma- Prof. Douglas Robinson
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27. Immunosuppressive mechanisms in myeloid cells- Prof. Dmitry Gabrilovich
Printable Handouts
Navigable Slide Index
- Introduction
- Osteoblasts and osteoclasts
- Osteoclasts (1)
- Osteoporosis (1)
- Osteoporosis (2)
- Bone remodeling (1)
- Bone remodeling (2)
- Bone remodeling (3)
- Bone remodeling (4)
- Osteoporosis (3)
- Osteopetrosis
- Osteopetrosis X-ray
- Increased bone mass and osteopetrosis
- Clinical forms of osteopetrosis
- Malignant osteopetrosis
- A patient with osteopetrosis
- Transplantation result
- Patient at the age of 3
- Patient at adulthood
- What is the osteoclast precursor?
- Hematopoietic precursor or stromal cell origin?
- Y-chromosome
- Y-body analysis of osteoclasts and osteoblasts
- The osteoclast precursor
- Osteoclast differentiation (1)
- Osteoprotogerin
- Osteoclast differentiation (2)
- RANK ligand gene deletion
- Osteoclast differentiation (3)
- Osteoclasts generated in vitro
- Osteoclastogenic signals
- Osteoclast differentiation and function (1)
- How does the osteoclast degrade bone?
- Isolated micro-environment formation
- Osteoclast proton pump
- Osteoclast proton pump mutation
- Osteoclast differentiation and function (2)
- Carbonic anhydrase
- Family with benign osteopetrosis
- Carbonic anhydrase deficiency
- Osteoclast differentiation and function (3)
- Osteoclast PH changes
- In the presence of Cl-
- Cl-/HCO3- exchange (1)
- Cl-/HCO3- exchange (2)
- SLC4A2- anion exchanger
- Osteoclast differentiation and function (4)
- Anion access
- Osteoclast chloride channel
- Bone resorption mechanism
- Chloride channel and osteopetrosis
- Osteoclast differentiation and function (5)
- Bone = mineral + organic matrix
- Organic matrix degrading enzyme
- Cathepsin K
- Pyknodysostosis
- Osteoclast differentiation and function (6)
- Osteoclast-bone attachment mechanism
- Integrin-matrix attachment (1)
- Integrin family
- Beta3-/- mice are osteopetrotic (1)
- Beta3-/- mice are osteopetrotic (2)
- The effect of integrin deletion on osteoclasts
- Osteoclast cytoskeleton
- Podosome
- Actin ring
- Osteoclast E/M
- Clues to the formation of the ruffled border (1)
- Clues to the formation of the ruffled border (2)
- Formation of the ruffled border-mechanism
- Synaptotagmins (Syt)
- Does SytVII organize the ruffled border?
- SytVII-/- osteoclasts have abnormal ruffled border
- SytVII-/- osteoclasts resorb bone poorly
- Integrin-matrix attachment (2)
- Integrin organizes the osteoclast cytoskeleton
- Summary
- Osteoclast differentiation and function (7)
Topics Covered
- Osteoclast
- Osteoporosis
- Bone remodeling
- Osteopetrosis
- Mechanisms of osteoclast formation
- Mechanisms of osteoclastic bone resorption
- Osteoclast cytoskeleton
Links
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Talk Citation
Teitelbaum, S.L. (2012, May 8). Osteoclasts: what do they do and how do they do it? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/NVQU7046.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Steven L. Teitelbaum has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Osteoclasts: what do they do and how do they do it?
Published on May 8, 2012
27 min
