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• 25 min
  1. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  2. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  3. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  4. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  5. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  6. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  7. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  8. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  9. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  10. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  11. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  12. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  13. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  14. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  16. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  17. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  18. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  19. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  20. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  21. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  22. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  23. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  24. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  25. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  26. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  27. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Transcription factors in macrophage differentiation
3. Differentiated cells
4. Definition by function
5. Definition by phenotype
6. Definition by ontogeny
7. Hematopoietic lineage
8. Macrophage lineage
9. Macrophage transcription factors
10. M-CSF cytokine sensitivity
11. Transcription factor control
12. Gain of function vs. loss of function mutations
13. C/EBPalpha KO
14. PU.1 KO (1)
15. PU.1 KO (2)
16. Early lineage commitment
17. Commitment
18. Transcription factor-cytokine interaction
19. Ectopic expression (1)
20. Ectopic expression (2)
21. Ectopic expression (3)
22. Summary I
23. Levels
24. Cross inhibition
25. Balance (1)
26. Balance (2)
27. Balance (3)
28. Successive competition
29. Combinatorial control
30. Integrated inhibition and cooperation
31. Changing complexes
32. Summary II
33. Enhancer definition
34. Cell type specific enhancers
35. ChIP-Seq enhancer definition
36. Comparing enhancers from different cell types
37. Cell type specific enhancer signature (1)
38. Cell type specific enhancer signature (2)
39. Global combinatorial enhancers
40. Polarization
41. Summary III
42. Control of cellular proliferation during differentiation
43. Recalling hematopoietic differentiation
44. Maf transcription factors
45. Maf transcription factors and cell differentiation
46. Maf overexpression
47. MafB overexpression
48. Maf/Myb in macrophage differentiation
49. Summary IV
50. Differentiation and cell cycle arrest are linked
51. MafB-/- macrophage differentiation
52. MafB,c-Maf parallel expression
53. MafB/c-Maf DKO macrophage differentiation
54. Differentiation and cell cycle arrest are linked
55. Differentiation & cell cycle arrest dissociation (1)
56. Differentiation & cell cycle arrest dissociation (2)
57. Mature adult macrophages
58. Unlimited self renewal
59. What is self renewal?
60. Maintained macrophage identity
61. Functional tissue integration
62. Non tumorigenic cells
63. c-Myc and KLF-4 dependence
64. Summary V
65. Thank you
66. References (1)
67. References (2)
68. References (3)
69. References (4)
70. References (5)

Topics Covered

• Control of cellular identity and cell numbers
• Gain and loss of function approaches
• Transcription factor/cytokine interplay
• Mechanism: transcription factor levels, balance and combinatorial control
• Enhancer definition of macrophage identity
• Differentiation and cell cycle control

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 14, 2012

Financial Disclosures

• Dr. Michael Sieweke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.