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1. Introduction
2. Outline
3. Autophagosomes have a distinct structure
4. Terminology
5. Membrane traffic
6. Yeast geneticists catalyze research
7. Conservation of autophagy components
8. Autophagy is inhibited by mTOR
9. Atg proteins govern autophagy
10. Reagents for autophagy research
11. Monitoring autophagosome formation
12. Monitoring autophagosome decay
13. Pathogens that encounter autophagy
14. Outcomes of microbe encounters
15. Basis for autophagosome accumulation
16. Ultrastructure of Legionella vacuole
17. Legionella route in permissive cells
18. GTPases promote vacuole biogenesis
19. Model: Legionella slows autophagy
20. NLR Naip5 implicated in autophagy
21. Naip5 facts
22. Model: inflammasomes induce autophagy
23. Crohn's disease links NLR, autophagy
24. Nod1 and 2 recruit Atg16L1 protein
25. Shigella evasion of autophagy
26. Listeria evasion of autophagy
27. Autophagy stimulates MHCII pathway
28. Autophagy stimulates MHCI pathway
29. Autophagy in infection and immunity
30. Acknowledgements

Topics Covered

• Autophagosome biogenesis
• Autophagy a regulated intersection of the secretory and endosomal pathways
• Genetic analysis in yeast has accelerated autophagy research
• Autophagy is inhibited by mTOR
• Autophagosome biogenesis is coordinated by a cascade of Atg proteins
• Autophagosomes mature rapidly in C57Bl/6 macrophages
• A wide variety of pathogens encounter the autophagy pathway
• Autophagy in infection and immunity
• Illustrations: Legionella pneumophila
• Shigella flexnerii
• Crohns' disease
• Mycobacterium tuberculosis
• Naip5 NOD-like receptor cytosolic surveillance protein
• Inflammasome components coordinate autophagy and pyroptosis as barriers to infection
• Autophagy enhances MHCI and MHCII antigen presentation

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. Michele Swanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.