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1. Introduction
2. Heat shock or stress proteins
3. Structure of HSP
4. Role of HSP
5. HSP are immuno-dominant (1)
6. HSP are immuno-dominant (2)
7. The mammalian Hsp70 family
8. HSPA1A chromosomal localization
9. Linear representation of human Hsp70 domains
10. Reactive systems in cell stress
11. HSP60 in arthritis and diabetes
12. HSP and atherosclerosis
13. Reduced plaque formation in HSP60 treated mice
14. HSP and disease
15. HSP60 in juvenile idiopathic arthritis
16. T cell responses
17. The nature of the immune response
18. HSP are no DAMPs (1)
19. HSP are no DAMPs (2)
20. Extracellular vs. intracellular
21. Microbial HSP promote immune regulation
22. HSP specific T cells and regulation
23. Proteoglycan-induced arthritis
24. HSP70 and PGIA (1)
25. HSP70 and PGIA (2)
26. HSP70 in IL10-null mice
27. Reasons for mapping Hsp70
28. The Hsp70 peptide B29
29. HSP70 B29 peptides suppress PGIA
30. Regulation by self-HSP specific T cells
31. Stress CMA and HSP70
32. Autophagy promotes MHC class II presentation
33. Regulatory T cells and HSP
34. Adoptive transfer Tregs in PGIA
35. Ag specific suppression by B29 Tregs
36. B29-induced CD4+CD25+ T cells suppress RA
37. Summary

Topics Covered

• Evolutionary conservation of heat shock proteins
• Models of autoimmunity and other inflammatory conditions
• Heat shock proteins induce regulatory T cells
• Heat shock proteins are targets of immunotherapeutic vaccines

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Van Eden, W. (2012, April 3). Heat shock proteins and their role in the immune regulation of inflammation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/VHPY6891.
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Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. Willem Van Eden, Stock Shareholder (Self-managed): Trajectum Pharma (a university based SME).