- TB-immune reconstitution inflammatory syndrome (IRIS) is a common complication of combined antitubercular and antiretroviral therapy
- The two forms of IRIS: paradoxical and unmasking
- Lack of a diagnostic test for TB-IRIS
- Expansion of Interferon gamma secreting T cells is associated with TB-IRIS
- Multiple cytokines are elevated in TB-IRIS, many of myeloid origin
- Benefits of adjunctive corticosteroid therapy in TB-IRIS
- Steroid therapy reduces the levels of IL-6, IL-10, IL-12p40, TNF, Interferon-gamma and CXCL-10 in TB-IRIS patients
- Suppurative necrosis may occur in TB-IRIS, implying a role for neutrophils
- Evidence of a prominent role for myeloid cells in the pathogenesis of TB-IRIS
Wilkinson, R. and Meintjes, G. (2012, April 3). The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks
. Retrieved June 10, 2023, from https://hstalks.com/bs/2279/
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Published on April 3, 2012
- Prof. Robert Wilkinson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Graeme Meintjes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.