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Printable Handouts
Navigable Slide Index
- Introduction
- Introduction to B cells
- Innate-like B cells (1)
- Innate-like B cells (2)
- Innate and adaptive mechanisms
- Innate-like B cells are similar to innate-like T cells
- Mouse B-1 cells
- The origin and maturation of B cells
- T cell dependent antibody responses
- Germinal centers
- Innate-like B cells have multiple characteristics
- Characteristics of Innate-like B cells
- Molecular targets of the innate immune system
- B1a antibody response to phosphorylcholine (PC)
- PC is a major component of organisms
- B1a subset
- Development of innate-like lymphocytes
- TEPC15Id expressing B cells (1)
- TEPC15Id expressing B cells (2)
- Some clones depend on TdT activity
- B1B + MZ
- Low affinity and high avidity antibodies
- Conserved antigens on a variety of organisms
- Chitin
- Monoclonal antibodies to GlcNAc bind chitin
- Alpha 1-3 glucans
- Sialyl-lacto-N-tetraose
- Antibodies to Aspergillus fumigatus
- The spleen: largest encapsulated lymph organ
- Special characteristics of the spleen
- Association between asplenia and OPSI
- A ruptured spleen is very dangerous
- The marginal zone forms an interface
- Anatomy of the mouse spleen
- Histological analysis of the mouse spleen
- Fluorescent-labeled bacteria to mouse spleen
- MZ B cells respond to blood-borne organisms
- Immune response in anti-PC Tg mice
- Innate-like B cells and protection against infection
- Human innate-like B cells
- Innate-like B cell derived antibodies: self-reactive
- Why these clones react to self antigens
- Functions of innate B cells and their products
- Summary
- Acknowledgements
Topics Covered
- Introduction to B cells
- Innate-like B cells
- Origin and function of innate-like B cells
- Targets of Innate-like B cell derived antibody
- Anatomy of Innate-B cell organ distribution
- Human Innate-like B cells and possible clinical applications
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Talk Citation
Kearney, J.F. (2012, April 3). Innate-like B cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 13, 2024, from https://doi.org/10.69645/RROF6947.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John F. Kearney has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.