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1. Introduction
2. NKT cells
3. Innate and adaptive immune cells
4. NKT cells: definition and classification
5. Thymic development of "type 1" or iNKT cells
6. Signaling required for iNKT cell development
7. T cell antigen receptors of iNKT cells
8. Remarkable level of conservation of iNKT cell TCRs
9. CD1d basic features
10. iNKT cells: natural & synthetic glycolipid antigens
11. Alpha-GalCer cancer activity immunological basis
12. Binding of Alpha-GalCer to CD1d
13. CD1d tetramers for identification of NKT cells
14. Identification of iNKT cells in tissues
15. Phenotypic subsets of iNKT cells defined by CD4
16. Functional differences between iNKT subsets cells
17. Bacterial glycolipids recognized by NKT cells
18. What lipids are presented by CD1d to iNKT cells?
19. Comparison of foreign and self antigen by CD1d
20. Basic features of iNKT cells: review
21. What do iNKT cells do?
22. Response to strong antigenic stimulus
23. Cytokine production by human iNKT cell clone
24. iNKT cell recognition of bacterial glycolipids
25. INKT activation following infection
26. Direct versus indirect activation of iNKT cells
27. iNKT cells contribute to resistance to infection
28. Anti-cancer effects of iNKT cell activation (1)
29. Anti-cancer effects of iNKT cell activation (2)
30. Different tissue iNKT cell & anticancer activity
31. Different phenotypic subsets & anticancer activity
32. Response to weak antigenic stimulus
33. Cytokine production by NKT cell clone DN2.D5
34. Diverse potential outcomes of NKT cell activation
35. Anti-inflammatory/regulatory effects of iNKT cells
36. Reduced NKT cells levels in autoimmune diseases
37. High expression of CD1d in spleen marginal zone
38. NKT cells regulate B cells
39. Enhanced anti-PC responses after immunization
40. Lupus, MZ B cells and iNKT cells?
41. iNKT cells regulate autoreactive B cell responses
42. Therapeutic manipulation of NKT cells
43. Synthetic analogues of alpha-GalCer KRN7000
44. Alpha-GalCer analogues
45. "TH2-like" bias: C20:2 and OCH analogues
46. Prevention of autoimmune type 1 diabetes mellitus
47. Overall summary and conclusions
48. Acknowledgments

Topics Covered

• Definition of NKT cells and their relation to other innate-like lymphocytes
• Development of NKT cells
• Mechanisms of glycolipid antigen recognition by NKT cells
• Frequency and phenotype of NKT cells
• Foreign and self antigens recognized
• Proinflammatory functions (anti-infectious and anti-tumor activities)
• Anti-inflammatory and tolerance-promoting functions
• Manipulation of NKT cell responses and therapeutic opportunities

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Porcelli, S.A. (2012, April 5). CD1d-restricted NKT cells: regulators of inflammation and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/ZERQ5342.
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Publication History

• Published on April 5, 2012

Financial Disclosures

• Prof. Steven A. Porcelli, Consultant: Vaccinex, Inc. (Rochester, NY).