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1. Introduction
2. Eukaryotic secretory pathway
3. Protein folding in the ER
4. Protein misfolding in the ER
5. ER-associated protein degradation: ERAD
6. The steps of ERAD
7. Substrate recognition
8. BiP recognition and targeting of ERAD substrates
9. N-linked glycosylation
10. Glycans as sorting signals
11. Mannose trimming as an ERAD signal
12. S. cerevisiae glycan mediated sorting
13. Mannose processing for ERAD (1)
14. Yeast ER mannosidases
15. Mannose processing for ERAD (2)
16. S. cerevisiae ERAD sorting and targeting
17. Mammalian ERAD pathway
18. Mammalian ER GH47 family members
19. EDEM1 complex
20. ER MRH domain family members
21. Os9 and XTP3-B complexes
22. ERAD selection and targeting - yeast-like model
23. ERAD selection and targeting: glycan adapter (1)
24. ERAD selection and targeting: glycan adapter (2)
25. Herp and VIMP ERAD adapter proteins
26. Possible ERAD translocons
27. Extraction of ERAD substrates
28. ER E3 ligases
29. ERAD pathways

Topics Covered

• Eukaryotic secretory pathway
• ER processes
• ERAD steps
• Substrate recognition
• Glycans as sorting signals
• Yeast ERAD process
• Mammalian ERAD process
• ERAD adapter proteins
• ERAD translocons
• ERAD E3 ligases

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Prof. Daniel Hebert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.