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Printable Handouts
Navigable Slide Index
- Introduction
- Astroglia
- Basic features of passive astrocytes
- Astrocytes occupy spatially separated domains (1)
- Astrocytes occupy spatially separated domains (2)
- Astrocytes occupy spatially separated domains (3)
- Astrocytes are inter-connected via gap junctions
- One astrocyte - many neurons, and vice versa
- Astroglia closely contact synaptic terminals
- Astrocytes - a revolutionary decade (1)
- Astrocytes show spontaneous calcium signalling
- Astrocytes respond to afferent stimulation
- Astrocyte stimulation triggers glutamate release
- Calcium elevation in astrocytes
- Astrocytes - the new concept
- Astrocyte-neuron signalling: potential concerns
- Effects of astrocyte endogenous calcium
- Monitoring astrocyte physiology and signalling
- How to suppress slow calcium elevations?
- A candidate (glio)transmitter signal
- Calcium signalling & NMDAR-dependent LTP
- Activation of the NMDAR co-agonist site
- Reducing NMDAR co-agonist site occupancy
- 750 nM DCKA blocks LTP
- LTP and the availability of NMDAR co-agonist sites
- LTP and the supply of D-serine by astrocytes
- No evidence of D-serine release by astrocytes
- Astrocytes extend their control of LTP induction (1)
- Astrocytes extend their control of LTP induction (2)
- Astrocytes extend their control of LTP induction (3)
- Tentative mechanisms to extend LTP control
- Conclusion
- The task
- Acknowledgements
- Thank you for your attention
Topics Covered
- Astroglia are the most abundant type of glial cells
- Their role has recently emerged as an active contributor to neural function
- The underlying mechanisms remain poorly understood
- Astrocytes release D-serine in a Ca2+ dependent manner
- Interference with this release reduces activation of synaptic NMDA receptors
- This in turn could severely impair induction of long-term synaptic potentiation
- Astroglia thus may play a fundamental role in mechanisms of memory formation in the brain
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Talk Citation
Rusakov, D. (2012, January 1). Regulation of synaptic plasticity by astroglia [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/AUDS2568.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dmitri Rusakov has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.