• Epidemiology and Risk Factors
• 41 min
  1. The changing prevalence of asthma

  • Dr. Deborah Jarvis
• 29 min
  2. Recent advances in asthma genetics

  • Prof. Miriam Moffatt
• 35 min
  3. Asthma: an epidemic caused by epigenetics?

  • Prof. David Schwartz
• 30 min
  4. Role of the microbiota in asthma

  • Prof. B. Brett Finlay
• 32 min
  5. Diet and asthma

  • Prof. Lewis Smith
• 43 min
  6. Obesity and asthma

  • Prof. Anne Dixon
• 35 min
  7. Occupational asthma: management beyond the textbooks

  • Prof. Paul Cullinan
• Clinical Phenotypes
• 42 min
  8. The origins of asthma

  • Prof. Peter Sly
• 46 min
  9. Pre-school wheeze

  • Prof. Andrew Bush
• 50 min
  10. Updates on the management of difficult asthma in school-aged children

  • Prof. Andrew Bush
• 24 min
  11. Smoking asthmatics

  • Prof. Neil Thomson
• 27 min
  12. Aspirin exacerbated respiratory disease

  • Prof. Chris Corrigan
• Mechanisms of Asthma
• 48 min
  13. Advances in asthma: airway inflammation

  • Prof. William Busse
• 48 min
  14. The role of mast cells in asthma

  • Prof. Peter Bradding
• 67 min
  15. Dendritic cells in asthma

  • Prof. Bart Lambrecht
• 30 min
  16. The airway smooth muscle in asthma

  • Prof. Judith Black
• 49 min
  17. Role of virus infection in asthma 1

  • Prof. Sebastian Johnston
• 27 min
  18. Role of virus infection in asthma 2

  • Prof. Sebastian Johnston
• 51 min
  19. Severe asthma: characterisation, mechanisms & treatment

  • Prof. Fan Chung
• 46 min
  20. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 26 min
  21. Macrophage in asthma

  • Prof. Douglas Robinson
• Diagnosis of Asthma
• 70 min
  22. Physiology of asthma and involvement of small airways

  • Prof. Charles G. Irvin
• 27 min
  23. Induced sputum in asthma

  • Prof. Antonio Spanevello
• 61 min
  24. Advances in asthma: the role of exhaled nitric oxide in the assessment and management of asthma

  • Prof. Robin Taylor
• Therapy and Management
• 41 min
  25. Pulmonary drug delivery

  • Prof. Anthony J. Hickey
• 32 min
  26. The management of chronic asthma

  • Prof. Mark Fitzgerald
• 21 min
  27. Inhaled corticosteroids and beta2-agonists

  • Dr. Omar S. Usmani
• 20 min
  28. Management of "difficult asthma"

  • Prof. Elisabeth Bel
• 47 min
  29. Management of acute exacerbations of asthma

  • Dr. Chris Fanta
• 34 min
  30. Non-pharmacological treatments for asthma

  • Prof. Neil Thomson
• 45 min
  31. Asthma: beyond the prescription

  • Prof. Martyn Partridge
• 45 min
  32. New drugs for asthma

  • Prof. Peter Barnes
• 24 min
  33. Anti-IgE therapy for asthma

  • Dr. Andrew Menzies-Gow
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  34. New drugs for asthma

  • Prof. Peter Barnes
• 35 min
  35. Asthma phenotypes in children

  • Prof. Andrew Bush
• 40 min
  36. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 42 min
  37. Severe asthma in children

  • Prof. Andrew Bush

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The airway in asthma is remodelled
3. Asthmatic and non-asthmatic airways
4. Big breakthrough in 2001
5. Asthmatic and non-asthmatic cell growth
6. Asthmatic Airway Smooth Muscle (ASM) cells
7. Airway smooth muscle and ECM
8. ECM production
9. Fibronectin expression with beclomethasone
10. Wound repair
11. Wound closure in asthmatic & non-asthmatic cells
12. TGFbeta and ASM
13. CTGF induction in bronchial segments
14. Altered matrix production
15. TGFbeta induces collagen and fibronectin mRNA
16. TGFbeta influence on non-asthmatic tissue
17. Human airway smooth muscle
18. CTGF influence on non-asthmatic tissue
19. TGFbeta signalling pathways
20. TGFbeta signalling pathways- pSMAD2
21. TGFbeta signalling pathway- CTGF
22. TGFbeta signalling pathways- collagen
23. TGFbeta signalling pathways- fibronectin
24. TGFbeta signalling
25. Effect of current therapies- corticosteroids
26. Effect of current therapies- beta2 agonists
27. Roflumilast
28. Bronchial rings
29. Conclusions so far
30. Increased fibulin-1 may mediate airway remodelling
31. Fibulin-1
32. Fibulin-1 increased in vivo
33. No difference in basal fibulin 1C or 1D mRNA
34. TGFbeta induces increased fibulin-1C mRNA
35. TGFbeta induces increased fibulin-1 protein (1)
36. TGFbeta induces increased fibulin-1 protein (2)
37. TGFbeta induces increased fibulin-1 in ECM
38. Fibulin-1C antisense decreases fibulin-1 in ECM
39. Fibulin-1 in ASM involved in wound repair
40. Fibulin-1 promotes proliferation of ASM
41. Fibulin-1 does not alter migration of ASM
42. Fibulin-1 regulates airway hyper-responsiveness
43. Fibulin-1 future goals
44. Thanks

Topics Covered

• Remodelling of the asthmatic airway
• Airway smooth muscle (ASM)
• increased deposition of matrix proteins
• Asthma increases ASM
• Characteristics of ASM cells in non-asthmatics
• Characteristics of ASM in asthmatics
• ASM produces extracellular matrix (ECM) proteins
• Differences in ECM in asthmatics
• Fibulin-1 in asthma
• Fibulin as a therapeutic target

Links

Series:

• Advances in Asthma

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011

Financial Disclosures

• Prof. Judith Black has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.