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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- The airway in asthma is remodelled
- Asthmatic and non-asthmatic airways
- Big breakthrough in 2001
- Asthmatic and non-asthmatic cell growth
- Asthmatic Airway Smooth Muscle (ASM) cells
- Airway smooth muscle and ECM
- ECM production
- Fibronectin expression with beclomethasone
- Wound repair
- Wound closure in asthmatic & non-asthmatic cells
- TGFbeta and ASM
- CTGF induction in bronchial segments
- Altered matrix production
- TGFbeta induces collagen and fibronectin mRNA
- TGFbeta influence on non-asthmatic tissue
- Human airway smooth muscle
- CTGF influence on non-asthmatic tissue
- TGFbeta signalling pathways
- TGFbeta signalling pathways- pSMAD2
- TGFbeta signalling pathway- CTGF
- TGFbeta signalling pathways- collagen
- TGFbeta signalling pathways- fibronectin
- TGFbeta signalling
- Effect of current therapies- corticosteroids
- Effect of current therapies- beta2 agonists
- Roflumilast
- Bronchial rings
- Conclusions so far
- Increased fibulin-1 may mediate airway remodelling
- Fibulin-1
- Fibulin-1 increased in vivo
- No difference in basal fibulin 1C or 1D mRNA
- TGFbeta induces increased fibulin-1C mRNA
- TGFbeta induces increased fibulin-1 protein (1)
- TGFbeta induces increased fibulin-1 protein (2)
- TGFbeta induces increased fibulin-1 in ECM
- Fibulin-1C antisense decreases fibulin-1 in ECM
- Fibulin-1 in ASM involved in wound repair
- Fibulin-1 promotes proliferation of ASM
- Fibulin-1 does not alter migration of ASM
- Fibulin-1 regulates airway hyper-responsiveness
- Fibulin-1 future goals
- Thanks
Topics Covered
- Remodelling of the asthmatic airway
- Airway smooth muscle (ASM)
- increased deposition of matrix proteins
- Asthma increases ASM
- Characteristics of ASM cells in non-asthmatics
- Characteristics of ASM in asthmatics
- ASM produces extracellular matrix (ECM) proteins
- Differences in ECM in asthmatics
- Fibulin-1 in asthma
- Fibulin as a therapeutic target
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Black, J. (2011, December 29). The airway smooth muscle in asthma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/JXLI5646.Export Citation (RIS)
Publication History
- Published on December 29, 2011
Financial Disclosures
- Prof. Judith Black has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The airway smooth muscle in asthma
Published on December 29, 2011
30 min
