On Sunday, April 20th 2025, starting 8:30am GMT, there will be maintenance work that will involve the website being unavailable during parts of the day. We apologize for any inconvenience this may cause and appreciate your understanding.
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Epidemiology and Risk Factors
-
41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
-
29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
-
35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
-
30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
-
32 min
5. Diet and asthma- Prof. Lewis Smith
-
43 min
6. Obesity and asthma- Prof. Anne Dixon
-
35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
-
42 min
8. The origins of asthma- Prof. Peter Sly
-
46 min
9. Pre-school wheeze- Prof. Andrew Bush
-
50 min
-
24 min
11. Smoking asthmatics- Prof. Neil Thomson
-
27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
-
48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
-
48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
-
67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
-
30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
-
49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
-
27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
-
51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
-
46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
-
26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
-
70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
-
27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
-
61 min
- Therapy and Management
-
41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
-
32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
-
21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
-
20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
-
47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
-
34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
-
45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
-
45 min
32. New drugs for asthma- Prof. Peter Barnes
-
24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
-
45 min
34. New drugs for asthma- Prof. Peter Barnes
-
35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
-
40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
-
42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- What constitutes and characterizes asthma?
- Airway inflammation
- What constitutes inflammation in asthma?
- Multiple components of inflammation in asthma
- Components of inflammation in asthma
- Key components of inflammation in asthma
- Mast cells in asthma
- The role of mast cells in asthma
- Biology of the airway response to antigen
- What happens if the mast cell is "disarmed"?
- Treatment with omalizumab on IgE-bearing cells
- Omalizumab effect on asthma - reference
- Omalizumab effect on asthma - study results
- Omalizumab effect on asthma exacerbations
- Omalizumab effect on asthma over a year
- Allergic sensitization and "September epidemics"
- What is the role of the eosinophil in asthma?
- Eosinophil
- Actions of IL-5
- Removing one of the inflammatory cells (1)
- The effect on lung function
- Mepolizumab reduces exacerbations
- Lymphocyte role in asthma
- Sub-populations of lymphocytes in asthma
- IL-4/13 actions
- IL-13 importance
- Gene expression microarray
- Expression of three genes induced by IL-13
- Expression levels of the Th2 cytokines
- Th2 high asthma patience response
- Responsiveness to inhaled steroids
- Characteristics of Th2-asthma phenotype
- Anti IL-13 effect
- Anti IL-13 study results
- Eosinophil sub populations
- Regulatory T cells
- TGF-beta
- Activating regulatory pathways
- Th17
- Th17 effect on asthma
- IL-17 and asthma
- Neutrophils and asthma
- IL-33 pathway
- IL-33
- IL-13 enhancing activity
- Summary
Topics Covered
- Airway inflammation is a complex, interactive, redundant immune response
- Components of inflammation in asthma
- "Traditional" inflammatory cells in airway inflammation
- Mast cells and eosinophils
- Lymphocytes
- Using monoclonal antibodies to gain insight into the clinical significance of inflammation in asthma
- IgE, IL-5, and IL-13
- The diversity of patterns of inflammation in asthma
- Personalized medicine
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Busse, W. (2012, February 19). Advances in asthma: airway inflammation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/XHFT8756.Export Citation (RIS)
Publication History
- Published on February 19, 2012
Financial Disclosures
- Prof. William Busse has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Advances in asthma: airway inflammation
Published on February 19, 2012
48 min
