• Epidemiology and Risk Factors
• 41 min
  1. The changing prevalence of asthma

  • Dr. Deborah Jarvis
• 29 min
  2. Recent advances in asthma genetics

  • Prof. Miriam Moffatt
• 35 min
  3. Asthma: an epidemic caused by epigenetics?

  • Prof. David Schwartz
• 30 min
  4. Role of the microbiota in asthma

  • Prof. B. Brett Finlay
• 32 min
  5. Diet and asthma

  • Prof. Lewis Smith
• 43 min
  6. Obesity and asthma

  • Prof. Anne Dixon
• 35 min
  7. Occupational asthma: management beyond the textbooks

  • Prof. Paul Cullinan
• Clinical Phenotypes
• 42 min
  8. The origins of asthma

  • Prof. Peter Sly
• 46 min
  9. Pre-school wheeze

  • Prof. Andrew Bush
• 50 min
  10. Updates on the management of difficult asthma in school-aged children

  • Prof. Andrew Bush
• 24 min
  11. Smoking asthmatics

  • Prof. Neil Thomson
• 27 min
  12. Aspirin exacerbated respiratory disease

  • Prof. Chris Corrigan
• Mechanisms of Asthma
• 48 min
  13. Advances in asthma: airway inflammation

  • Prof. William Busse
• 48 min
  14. The role of mast cells in asthma

  • Prof. Peter Bradding
• 67 min
  15. Dendritic cells in asthma

  • Prof. Bart Lambrecht
• 30 min
  16. The airway smooth muscle in asthma

  • Prof. Judith Black
• 49 min
  17. Role of virus infection in asthma 1

  • Prof. Sebastian Johnston
• 27 min
  18. Role of virus infection in asthma 2

  • Prof. Sebastian Johnston
• 51 min
  19. Severe asthma: characterisation, mechanisms & treatment

  • Prof. Fan Chung
• 46 min
  20. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 26 min
  21. Macrophage in asthma

  • Prof. Douglas Robinson
• Diagnosis of Asthma
• 70 min
  22. Physiology of asthma and involvement of small airways

  • Prof. Charles G. Irvin
• 27 min
  23. Induced sputum in asthma

  • Prof. Antonio Spanevello
• 61 min
  24. Advances in asthma: the role of exhaled nitric oxide in the assessment and management of asthma

  • Prof. Robin Taylor
• Therapy and Management
• 41 min
  25. Pulmonary drug delivery

  • Prof. Anthony J. Hickey
• 32 min
  26. The management of chronic asthma

  • Prof. Mark Fitzgerald
• 21 min
  27. Inhaled corticosteroids and beta2-agonists

  • Dr. Omar S. Usmani
• 20 min
  28. Management of "difficult asthma"

  • Prof. Elisabeth Bel
• 47 min
  29. Management of acute exacerbations of asthma

  • Dr. Chris Fanta
• 34 min
  30. Non-pharmacological treatments for asthma

  • Prof. Neil Thomson
• 45 min
  31. Asthma: beyond the prescription

  • Prof. Martyn Partridge
• 45 min
  32. New drugs for asthma

  • Prof. Peter Barnes
• 24 min
  33. Anti-IgE therapy for asthma

  • Dr. Andrew Menzies-Gow
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  34. New drugs for asthma

  • Prof. Peter Barnes
• 35 min
  35. Asthma phenotypes in children

  • Prof. Andrew Bush
• 40 min
  36. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 42 min
  37. Severe asthma in children

  • Prof. Andrew Bush

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Overview
3. What constitutes and characterizes asthma?
4. Airway inflammation
5. What constitutes inflammation in asthma?
6. Multiple components of inflammation in asthma
7. Components of inflammation in asthma
8. Key components of inflammation in asthma
9. Mast cells in asthma
10. The role of mast cells in asthma
11. Biology of the airway response to antigen
12. What happens if the mast cell is "disarmed"?
13. Treatment with omalizumab on IgE-bearing cells
14. Omalizumab effect on asthma - reference
15. Omalizumab effect on asthma - study results
16. Omalizumab effect on asthma exacerbations
17. Omalizumab effect on asthma over a year
18. Allergic sensitization and "September epidemics"
19. What is the role of the eosinophil in asthma?
20. Eosinophil
21. Actions of IL-5
22. Removing one of the inflammatory cells (1)
23. The effect on lung function
24. Mepolizumab reduces exacerbations
25. Lymphocyte role in asthma
26. Sub-populations of lymphocytes in asthma
27. IL-4/13 actions
28. IL-13 importance
29. Gene expression microarray
30. Expression of three genes induced by IL-13
31. Expression levels of the Th2 cytokines
32. Th2 high asthma patience response
33. Responsiveness to inhaled steroids
34. Characteristics of Th2-asthma phenotype
35. Anti IL-13 effect
36. Anti IL-13 study results
37. Eosinophil sub populations
38. Regulatory T cells
39. TGF-beta
40. Activating regulatory pathways
41. Th17
42. Th17 effect on asthma
43. IL-17 and asthma
44. Neutrophils and asthma
45. IL-33 pathway
46. IL-33
47. IL-13 enhancing activity
48. Summary

Topics Covered

• Airway inflammation is a complex, interactive, redundant immune response
• Components of inflammation in asthma
• "Traditional" inflammatory cells in airway inflammation
• Mast cells and eosinophils
• Lymphocytes
• Using monoclonal antibodies to gain insight into the clinical significance of inflammation in asthma
• IgE, IL-5, and IL-13
• The diversity of patterns of inflammation in asthma
• Personalized medicine

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on February 19, 2012

Financial Disclosures

• Prof. William Busse has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.