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1. Introduction
2. Epigenetic marks and risk of developing asthma
3. Epigenetic: control of gene expression
4. Epigenetic mechanisms
5. In utero diet can alter the epigenome
6. Aguti gene
7. Aging and epigenetic marks
8. Histone modifications and innate immunity
9. CpG motif methylation
10. Asthma is a major public health problem
11. Epigenetics and airway immunology
12. DNA methylation changes and asthma
13. High vs. low methylation diet
14. Airway resistance in high vs. low methylation diet
15. Epigenetics and asthma
16. Transgenerational transmission of asthma to F2 (1)
17. Transgenerational transmission of asthma to F2 (2)
18. 82 hypermethylated loci among HMD progeny
19. Runx3 and airway disease
20. New biological targets
21. In utero folate supplementation and asthma
22. Asthma and epigenetics in humans
23. Sib pair asthma study - preliminary analysis
24. Global methylation patterns
25. Genome-wide DMR
26. Distribution of 873 DMRs from CpG islands
27. Hypomethylation of GATA3
28. Hypomethylation of MUC5B
29. Hypermethylation of NOS2
30. Additional approaches
31. Summary
32. Acknowledgment

Topics Covered

• Genetic and biological determinants of diseases influenced by the environment
• Epigenetics
• Epigenetic mechanisms can be influenced by environmental exposures and aging
• Histone modifications and innate immunity
• Asthma is a major public health problem
• Epigenetics and airway immunology
• DNA methylation changes and asthma
• Runx3 and airway disease
• In utero folate supplementation and asthma
• Sib pair asthma study
• Preliminary analysis
• Global methylation patterns: asthmatics vs. nonasthmatics
• Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs
• Hypermethylation of NOS2 is associated with concordant asthma
• Asthma: an epidemic caused by epigenetics?

Links

Series:

• Advances in Asthma

Categories:

• Cell Biology
• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011
• Reviewed on October 11, 2020

Financial Disclosures

• Prof. David Schwartz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.