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• 52 min
  1. Principles of cytokine-receptor interactions and signal transduction

  • Dr. Xiaoxia Li
• 47 min
  2. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 74 min
  3. Cytokines and CD4 T Cells: dance partners at the immunology ball

  • Dr. William E. Paul
• 38 min
  4. The gamma c family of cytokines

  • Dr. Warren J. Leonard
• 29 min
  5. Interleukin-6: back to the future

  • Prof. Tadamitsu Kishimoto
• 59 min
  6. Regulation of the immune response to pathogens 1

  • Prof. Anne O’Garra
• 33 min
  7. Regulation of the immune response to pathogens 2

  • Prof. Anne O’Garra
• 23 min
  8. IL-17 cytokine family and receptors

  • Prof. Chen Dong
  • Dr. Seon Hee Chang
• 40 min
  9. The b common (bc) family of cytokines, receptors and ligands

  • Prof. Angel Lopez
  • Dr. Timothy Hercus
• 29 min
  10. TNF superfamily cytokines and receptors in the healthy and diseased immune system

  • Dr. Richard Siegel
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 49 min
  12. IL-1 as a key inflammatory regulator in autoinflammatory diseases

  • Dr. Raphaela Goldbach-Mansky
• 58 min
  13. Signaling for the interferon family of receptors and ligands and clinical implications

  • Prof. Leonidas Platanias
• 45 min
  14. Interferons as antivirals: translating basic research into clinical application

  • Prof. Eleanor N. Fish
• 49 min
  15. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 22 min
  16. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  17. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 49 min
  18. Receptor identification for alarmins and DAMPs

  • Dr. Joost J. Oppenheim
• 41 min
  19. Assays for cytokines and cytokine assay performance 1

  • Prof. Theresa Whiteside
• 39 min
  20. Assays for cytokines and cytokine assay performance 2

  • Prof. Theresa Whiteside
• 23 min
  21. Interleukin-7 and T cells

  • Dr. Scott Durum
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  22. Assays for cytokines and cytokine assay standardization

  • Prof. Theresa Whiteside

Printable Handouts

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Navigable Slide Index

1. Introduction
2. hBD2's chemotactic effect and receptor
3. DCs' activating effect of beta-defensin-2
4. Alarmins recruit and activate APC
5. Definition of DAMPs
6. Antimicrobial proteins act as alarmins
7. Mechanism of action of alarmins: granulysin
8. Granulysin activates DCs by TLR4
9. Anti-granulysin blocks the DC-activating effect
10. NK92 supernatant activates DCs by TLR4
11. No endotoxin contamination in granulysin effect
12. Alarming effects of granulysin
13. Why study HMGN1?
14. HMGN1 induction of DC recruitment
15. HMGN1 induces phenotypic maturation of DCs
16. HMGN1 induces functional maturation of DCs
17. HMGN1 promotes Th1-OVA immune response
18. HMGN1 acts like a cytokine
19. HMGN1 induced multiple signaling pathways
20. DCs activation was MyD88 and TRIF -dependent
21. HMGN1 activation of DCs was TLR4 -dependent
22. HMGN1 expressed in insect cells was active
23. Synthetic peptide of HMGN1 activates DCs
24. HMGN1 interacts with MD2
25. HMGN1 behaves like a non-leukocytic cytokine
26. Hmgn1 KO mice can't produce cytokines
27. Hmgn1 KO mice have deficient immune response
28. How Hmgn1 promotes immune responses (1)
29. How Hmgn1 promotes immune responses (2)
30. KO mice show reduced leukocytes recruitment
31. HMGN1 derived from non-leukocytes
32. EG7 tumor grew rapidly in Hmgn1 KO mice
33. HMGN1-induced DC signaling and activation
34. HMGN1 is a key alarmin
35. Alarmin-TAA fusion induces anti-tumor immunity
36. Potent Th1/Th2 polarizing alarmins
37. Alarmin-like/DAMP's
38. Acknowledgements

Topics Covered

• Definition of Alarmins and Damps
• History of discovery that antimicrobial peptides such as Beta Defensins recruit and activate immune cells engaged in host defense
• Identification of other antimicrobials such as granulysin and nuclear binding factors, e.g. HMGN1, as also acting as alarmins that activate receptors on host cells
• Proposal to use some alarmins as vaccine adjuvants

Links

Series:

• Cytokines

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on December 5, 2011

Financial Disclosures

• Dr. Joost J. Oppenheim has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.