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1. Introduction
2. Talk outline
3. IL-1 has many names
4. IL-1 is a pleiotropic cytokine
5. IL-1 biology
6. IL-1 effects on non-hematopoietic tissues
7. IL-1 effects on the innate immune system
8. IL-1 effects on the adaptive immune system
9. IL-1 molecules & receptors
10. IL-1alpha and IL-1beta
11. IL-1 receptor type 1
12. IL-1 binds to the type 1 IL-1 receptor
13. The IL-1 receptor is a heterodimer
14. The IL-1 family
15. IL-1Ra does not signal
16. Type 2 IL-1 receptor is a decoy receptor
17. Type 2 IL-1R decoys IL-1 but not IL-1Ra
18. IL-1 secretion, signaling, and regulation
19. IL-1 processing and secretion
20. IL-1 signaling
21. IL-1 regulation
22. IL-1 and disease
23. IL-1 mediated diseases (1)
24. IL-1 mediated diseases (2)
25. IL-1 disease association (1)
26. IL-1 disease association (2)
27. IL-1 inhibitors
28. Other IL-1 family members
29. IL-1 family members (as of 2011)
30. IL-1 family tree
31. IL-3 three dimensional structures
32. IL-1 locus
33. IL-1 receptor family (1)
34. IL-1 receptor family (2)
35. IL-18bp regulates IL-18 signaling
36. Soluble receptors regulate IL-33
37. IL-36Ra antagonizes IL-36 signaling
38. SIGIRR regulates all of IL-1, IL-18, IL-33 and IL-36
39. IL-1 family members in T cell polarization
40. IL-18 biology and disease association
41. IL-18 biology
42. IL-18 disease association
43. IL-33
44. IL-33 biology
45. Association of IL-33 and asthma (1)
46. IL-33 affects IL-33R in asthma-associated cells
47. Association of IL-33 and asthma (2)
48. IL-33 drives asthma by several mechanisms
49. IL-36 and psoriasis
50. IL-36 tissue expression pattern
51. IL-36 cytokines are processed
52. IL-36 truncation enhances their activity
53. IL-36 is over-expressed in psoriatic skin
54. IL-36alpha over-expression in mice (1)
55. IL-36alpha over-expression in mice (2)
56. IL-36 cytokines play a role in psoriasis
57. Inhibition of IL-36 ameliorates human psoriasis
58. IL-37
59. Conclusions
60. Additional reading

Topics Covered

• Introduction to IL-1 and its biology
• Molecular characterization of IL-1 and its receptor
• IL-1 secretion, signaling and regulation
• IL-1 disease association
• Other members of the IL-1 family, including structure, expression, receptors, regulation
• IL-18
• IL-33 and asthma
• IL-36 and psoriasis

Links

Series:

• Cells of the Innate Immune System
• Cytokines

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Sims, J. (2011, December 5). An introduction to the interleukin-1 family of cytokines [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/KLBG4190.
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Publication History

• Published on December 5, 2011

Financial Disclosures

• Dr. John Sims, Other: owns stock and stock options in Amgen; was an Amgen employee until 1 Jan 2012.