Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Overview
3. Human gastrointestinal tract
4. Diversity along GI tract
5. Bacterial species distribution
6. Role of microbiota in digestion
7. Normal microbiota - development
8. Normal microbiota - contributing factors
9. Impact of disease
10. Omics pipeline
11. Omics technologies
12. Fingerprinting of the gut microbiota
13. Inflammatory bowel disease
14. Crohn's disease (CD)
15. CD - symptoms
16. CD - complications
17. Etiology of Crohn's Disease unknown
18. CD - hypothothesis
19. Evidence for microbial involvement in IBD
20. Dysbiosis definition
21. Genetics and IBD
22. Value of twin studies
23. Swedish twin cohort
24. PCA of T-RFLP profiles (healthy)
25. PCA of T-RFLP profiles (diseased)
26. PCA of T-RFLP profiles (ileal differentiate)
27. Similarity indices by two methods
28. Value of biopsies
29. Abundance of faecalibacterium in T-RFLP data
30. Abundance of faecalibacterium by 3 methods
31. Faecalibacterium prausnitzii: butyrate producer
32. Abundance of E. coli in 454 data
33. Potential microbial biomarkers of CD
34. Omics pipeline - metaproteomics
35. Genomics vs. proteomics
36. Fecal metagenomes and metaproteomes
37. Comparison of normalized metaproteomes
38. Almost 30% of proteins were human
39. Metaproteomics of twins with Crohn's disease
40. Clustering of proteins according to disease
41. Comparison of species composition
42. Clusters of abundant proteins
43. Omics pipeline - metametabolome
44. Meta "metabolomics"
45. Sample preparation method
46. Clustering of metabolites according to disease
47. Total masses
48. Bile acid biosynthesis
49. Summary of metabolite data
50. Concluding remarks
51. Acknowledgements

Topics Covered

• Human gastrointestinal tract
• The normal microbiota: development and contributing factors
• Impact of disease on the human intestinal microbiota and vice versa
• Fingerprinting of the gut microbiota
• Crohn's disease: symptoms, complications, etiology
• Evidence for microbial involvement in IBD
• Dysbiosis
• Genetics and IBD
• Twin studies
• Genomics vs. proteomics
• Metaproteomics and metagenomics
• Metabolite data

Links

Series:

• Microbiota

Categories:

• Clinical Practice
• Microbiology

Talk Citation

Publication History

• Published on October 27, 2011

Financial Disclosures

• Prof. Janet Jansson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.