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Navigable Slide Index

1. Introduction
2. Spinal cord injury
3. Treatments for spinal cord injury
4. Need for suitable models
5. Human spinal cord injuries (1)
6. Human spinal cord injuries (2)
7. Human SCI: age & sex
8. Human SCI: spinal level of injury
9. Human SCI: mechanisms of injury
10. Experimental SCI models
11. Potential sources of variance
12. Weight drop devices
13. Force controlled devices
14. Depth of tissue penetration
15. Position control: linear motors
16. Linear motor based impactor
17. Position controlled devices
18. Consistency of initial lesions
19. Primary tissue damage
20. Timing of tissue loss after SCI
21. Secondary tissue damage
22. Secondary loss of grey matter
23. Secondary loss of white matter (1)
24. Secondary loss of white matter (2)
25. Secondary loss of white matter (3)
26. Secondary loss of oligodendrocytes (1)
27. Secondary loss of oligodendrocytes (2)
28. Assessing tissue sparing at lesion centre
29. Assessing function: BBB score
30. Assessing motor function
31. Summary
32. Acknowledgements

Topics Covered

• Development of neuro-protective therapies
• Need for suitable experimental models
• Low variance reproducible lesions
• Spatio-temporal pattern of grey and white matter damage

Links

Series:

• Neurotrauma

Categories:

• Clinical Practice
• Methods
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Habgood, M. (2011, October 27). Experimental models for assessing treatments for spinal cord injury [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ATKS8762.
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Publication History

• Published on October 27, 2011

Financial Disclosures

• Dr. Mark Habgood has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.