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1. Introduction
2. Ilya Mechnikov
3. Host-mediated detection of microbes
4. The nod-like receptor family
5. Nod1 and Nod2
6. Nod1 is a sensor for a peptidoglycan (1)
7. Nod1 is a sensor for a peptidoglycan (2)
8. Nod1 is a sensor for a peptidoglycan (3)
9. Nod2 is a sensor for a peptidoglycan
10. Nod1 & Nod2 recognize bacterial peptidoglycan
11. Role of Nod1 in infected intestinal epithelial cells
12. Nod1 and Nod2 are intracellular PRMs
13. How Nod ligands get access to host cytosol
14. Muramyl peptides - activity requires internalization
15. Nod1 ligands: structure and activity (1)
16. Nod1 ligands: structure and activity (2)
17. Nod1 ligands escape the endocytic pathway
18. Model - how Nod ligands enter the host cytosol
19. SLC15A4 is a transporter for Nod1 ligands
20. Upregulation of SLC15A4 in disease
21. Nod2 and Crohn's disease
22. Nod-like receptor & auto-inflammatory disorders
23. Expression of functional Nod2 in epithelial cells
24. The 3020insC frame-shift mutation of Nod2 (1)
25. The 3020insC frame-shift mutation of Nod2 (2)
26. Other Crohn's disease associated Nod2 mutations
27. Models explaining the Nod2 loss & CD paradox
28. Loss of antimicrobial activity
29. MDP triggers antimicrobial peptide secretion
30. Defective induction of defensins
31. Decreased production of NO
32. Production of antimicrobial ROS
33. Nod2 mutation in CD-gain of function mutation (1)
34. Nod2 mutation in CD-gain of function mutation (2)
35. Negative regulation of Th1 responses by Nod2
36. Defective Nod2 targeting to plasma membrane
37. Defective polarization of Th2 immune responses
38. More recent models - autophagy
39. ATG16L1 and Crohn's disease (1)
40. ATG16L1 and Crohn's disease (2)
41. ATG16L1 and Crohn's disease (3)
42. Bacterial autophagy
43. Nod2fs cells fail to direct autophagy
44. Nod2 brings ATG16L1 to the membrane
45. Nod1/Nod2 direct autophagy to bacterial entry site
46. More recent models- the IL-17/IL-22 axis
47. Delayed histopathology in Nod1/2 DKO mice
48. Early IL-17 responses are Nod1/2 dependent (1)
49. Early IL-17 responses are Nod1/2 dependent (2)
50. Specific cells produce IL-17/22 early
51. Lack of early Th17 response NOD1/2 KNO mice
52. Working model
53. General conclusions

Topics Covered

• Innate immunity
• Host detection of intracellular bacterial pathogens by Nod-like receptors
• Dysregulation of intestinal immune control of bacteria
• Crohn's disease

Links

Series:

• Microbiota

Categories:

• Clinical Practice
• Microbiology

Talk Citation

Girardin, S. (2011, September 27). Nod proteins in mucosal defense against bacteria: implications for Crohn's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/LOME2381.
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Publication History

• Published on September 27, 2011

Financial Disclosures

• Dr. Stephen Girardin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.