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1. Introduction
2. Autoantibodies content as a disease "fingerprint"
3. Major topics of this lecture
4. Medical challenges (1)
5. Medical challenges (2)
6. Inflammatory rheumatic disease (IRD) diagnostics
7. Diagnostics/prognostics of IRD
8. Optimal user-defined needs
9. Tests used for diagnosis of a disease
10. Laboratory aspects 2006
11. Laboratory medicine 2006
12. Indicating clinical value of test results (1)
13. Indicating clinical value of test results (2)
14. Sensitive assays
15. Example: anti-dsDNA antibodies determination
16. Screening by indirect immunofluorescence (IIF)
17. My postulate
18. Cellular regions: HEp-2 cells
19. Modern testing platforms: are they better?
20. Autoantigen arrays
21. Addressable laser bead immuno-assay
22. Reading the reactions
23. Limitations of solid phase assays
24. Diagnosis vs. differential diagnosis
25. Criteria-based clinical diagnostics
26. Ideal clinical and laboratory collaboration (1)
27. Ideal clinical and laboratory collaboration (2)
28. Making diagnostics appropriate
29. Achieving early diagnosis of IRD
30. Example of an algorithm
31. Principle of autoimmune test guide
32. Algorithm for clinical utility
33. Autoantibody-associated sub-syndromes of IRDs
34. Autoantibody-associated lupus sub-syndromes
35. ANA in glomerular lesions of SLE patients
36. Production of ANA before SLE onset (1)
37. Production of ANA before SLE onset (2)
38. Production of antiphospholipids before SLE onset
39. Genes and autoantibody production in SLE
40. Infrequent ANAs are important
41. Scleroderma: survival rates
42. Anti-centromere associations: limited scleroderma
43. Anti-Th/To RNP associations: limited scleroderma
44. Anti-Scl-70 associations: diffuse scleroderma
45. Anti-RNA pol I associations: diffuse scleroderma
46. Anti-U3 RNP associations: diffuse scleroderma
47. Anti-U1RNP associations: overlap scleroderma
48. Anti-PM/Scl associations: overlap scleroderma
49. Evidence-based laboratory medicine
50. Ultimate importance: clinical outcome
51. Perspectives: health economics
52. Conclusions (1)
53. Conclusions (2)
54. Conclusions (3)
55. Some references

Topics Covered

• Tests to diagnose autoimmune rheumatic diseases
• Parameters to indicate clinical value of test results
• Tests based on different technologies
• Making diagnostics clinically appropriate
• Algorithms for use in family practice and in rheumatology practice
• Detection of early autoimmune disease
• Value for money has to be based on optimal early diagnostic work-up

Links

Series:

• Autoimmunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Wiik, A. (2007, October 1). Use of algorithms for high quality diagnostics and handling of patients with autoimmune rheumatic diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/206/.
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Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Allan Wiik has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.