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1. Introduction
2. Microglia and oligodendrocytes
3. Microglia
4. Development of microglia
5. Embryonic microglia
6. Adult microglia
7. Activated microglia
8. Microglial processes monitor the environment
9. Pathological signals activate microglia
10. Roles of purine receptors in microglial activation
11. Microglia and pathogenic pain
12. Oligodendrocytes
13. Degeneration
14. Peripheral nervous system (PNS) degeneration
15. Schwann cells (SC) in PNS injury
16. Central nervous system (CNS) degeneration
17. Nogo is a major myelin inhibitory molecule
18. Myelin contains multiple axon growth inhibitors
19. Myelin proteins inhibit axon growth - mechanisms
20. Oligodendrocyte precursor cells (NG2-glia)
21. Demyelination
22. Multiple Sclerosis (MS) involves all glial cell types
23. Diverse factors involved in MS
24. Glutamate is cytotoxic for oligodendrocytes
25. Ischemic cell death in immature oligodendrocytes
26. ATP acting on P2X7 receptors in demyelination
27. MS is characterised by white matter lesions
28. Relapse remitting MS
29. Acute phase of MS
30. Active lesions in MS
31. Remyelination in MS
32. Neurodegeneration in MS
33. Chronic (inactive) MS lesions
34. Why does remyelination ultimately fail in MS?
35. Conclusions

Topics Covered

• Microglia
• Oligodendrocytes
• Degeneration
• SC in PNS injury
• CNS degeneration
• Mechanisms of axon growth inhibition by myelin proteins
• Oligodendrocyte precursor cells (NG2-glia)
• Demyelination
• Multiple sclerosis

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on July 19, 2011

Financial Disclosures

• Prof. Arthur M. Butt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.