• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Expression of neurotransmitter receptors
3. Receptor expression patterns in neurons and glia
4. Astrocyte-neuronal communication via channels
5. Neurotransmission by glutamate
6. Ionotropic glutamate receptors
7. Neurotransmitter receptors in astrocytes
8. Calcium influx into glia mediated by AMPARs
9. NMDA receptors in astroglial cells
10. Glutamate induces a complex current response
11. NMDA current response is glycine-sensitive
12. NMDA receptors are magnesium insensitive
13. Metabotropic receptors
14. Parallel fiber stimulation triggers Ca signals in glia
15. Glutamate transporters
16. Astrocytes - important in glutamate-uptake in CNS
17. GluT and AMPAR-mediated currents
18. Glu induces inward current and sodium influx
19. Glial Glu sensors help control extracellular Glu
20. ATP - in neuronal-glial networks
21. ATP-mediated transmission: the beginning
22. ATP: the primordial signalling molecule
23. Mechanisms of ATP release in the CNS
24. ATP release and degradation in the CNS
25. Exocytotic ATP release from synaptic terminals
26. Quantal release of ATP from cortical astrocytes
27. Purinoceptors: an overview
28. ATP-a universal transmitter (neural-glial network)
29. ATP receptors in astroglia trigger calcium signals
30. ATP universal glial transmitter - oligodendrocytes
31. ATP-induced currents in cortical astrocytes
32. ATP currents are concentration-dependent
33. Pharmacology of ATP-induced currents
34. Subunit composition of the astroglial P2X receptor
35. Cortical astrocytes express P2X1 & P2X5 subunits
36. Synaptic stimulation triggers astroglial currents
37. Glial synaptic currents (GSC) in the neocortex
38. Ionotropic receptors and GluT mediate GSC
39. Spontaneous glial synaptic currents
40. Calcium permeability of astroglial receptors
41. NMDA, P2X1/5 receptors are calcium permeable
42. NMDARs/P2X1/5Rs stimulation triggers Ca signals
43. Ca signals via ionotropic receptors
44. Astroglial ionotropic receptors are remodelled
45. In situ recordings from ageing cortical astroglia
46. GSC relative weight changes with age
47. Ageing modifies receptor expression in astroglia
48. Ageing affects ionotropic Ca signalling in astroglia
49. Effects of intracellular Na elevation
50. Conclusions

Topics Covered

• Ionotropic receptors
• Metabotropic receptors
• Glutamate transporters
• ATP: principal transmitter in neuronal-glial networks
• Mechanisms of ATP release in the central nervous system
• Ionotropic receptors and glutamate transporters mediating astroglial currents
• Calcium permeability of astroglial NMDA and P2X1/5 receptors
• Age-dependent remodelling of ionotropic receptors expression in cortical astroglia

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 29, 2011

Financial Disclosures

• Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.