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Printable Handouts
Navigable Slide Index
- Introduction
- Expression of neurotransmitter receptors
- Receptor expression patterns in neurons and glia
- Astrocyte-neuronal communication via channels
- Neurotransmission by glutamate
- Ionotropic glutamate receptors
- Neurotransmitter receptors in astrocytes
- Calcium influx into glia mediated by AMPARs
- NMDA receptors in astroglial cells
- Glutamate induces a complex current response
- NMDA current response is glycine-sensitive
- NMDA receptors are magnesium insensitive
- Metabotropic receptors
- Parallel fiber stimulation triggers Ca signals in glia
- Glutamate transporters
- Astrocytes - important in glutamate-uptake in CNS
- GluT and AMPAR-mediated currents
- Glu induces inward current and sodium influx
- Glial Glu sensors help control extracellular Glu
- ATP - in neuronal-glial networks
- ATP-mediated transmission: the beginning
- ATP: the primordial signalling molecule
- Mechanisms of ATP release in the CNS
- ATP release and degradation in the CNS
- Exocytotic ATP release from synaptic terminals
- Quantal release of ATP from cortical astrocytes
- Purinoceptors: an overview
- ATP-a universal transmitter (neural-glial network)
- ATP receptors in astroglia trigger calcium signals
- ATP universal glial transmitter - oligodendrocytes
- ATP-induced currents in cortical astrocytes
- ATP currents are concentration-dependent
- Pharmacology of ATP-induced currents
- Subunit composition of the astroglial P2X receptor
- Cortical astrocytes express P2X1 & P2X5 subunits
- Synaptic stimulation triggers astroglial currents
- Glial synaptic currents (GSC) in the neocortex
- Ionotropic receptors and GluT mediate GSC
- Spontaneous glial synaptic currents
- Calcium permeability of astroglial receptors
- NMDA, P2X1/5 receptors are calcium permeable
- NMDARs/P2X1/5Rs stimulation triggers Ca signals
- Ca signals via ionotropic receptors
- Astroglial ionotropic receptors are remodelled
- In situ recordings from ageing cortical astroglia
- GSC relative weight changes with age
- Ageing modifies receptor expression in astroglia
- Ageing affects ionotropic Ca signalling in astroglia
- Effects of intracellular Na elevation
- Conclusions
Topics Covered
- Ionotropic receptors
- Metabotropic receptors
- Glutamate transporters
- ATP: principal transmitter in neuronal-glial networks
- Mechanisms of ATP release in the central nervous system
- Ionotropic receptors and glutamate transporters mediating astroglial currents
- Calcium permeability of astroglial NMDA and P2X1/5 receptors
- Age-dependent remodelling of ionotropic receptors expression in cortical astroglia
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Talk Citation
Verkhratsky, A. (2011, June 29). Neuronal-glial chemical transmission mediated by glutamate and ATP [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/EUAH6661.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.