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1. Introduction
2. Astrocytes - the homeostatic cells of the brain
3. Astrocytes may be labelled with GFAP antibodies
4. Heterogeneity of astrocytes (morphological)
5. Heterogeneity of astrocytes (functional)
6. Functions of astroglia
7. Embryonic neuro- and glio- genesis
8. Radial glial act as pathfinders for neuroblasts
9. Adult neurogenesis
10. Astrocytes promote and regulate synaptogenesis
11. Astrocytes control functional status of synapses
12. Defining functional architecture of grey matter
13. Astrocytes divide the grey matter into domains
14. Discovery of the BBB by Paul Ehrlich
15. Evolution of the BBB
16. Blood-Brain barrier - glial-vascular interface
17. Astroglial perivascular processes
18. Molecular traffic mechanisms through the BBB
19. Atrocytes regulate BBB development & function
20. The brain is one of the most vascularised organs
21. Astrocytes create neurovascular units
22. Brain energetics (1)
23. Brain energetics (2)
24. Lactate shuttle
25. Potassium buffering
26. Potassium siphoning in the single Muller glial cell
27. Control over water movements/redistribution
28. Astrocytes control brain glutamate homeostasis
29. Astrocytes are essential for Na+ homeostasis
30. Astrocytes provide CO2/H+ chemosensitivity
31. Signalling in neuronal-glial networks
32. The tripartite synapse
33. Tripartite synapse versus astroglial cradle
34. Propagating signalling waves in glial syncytium
35. Astrocytes as secretory cells
36. Signalling through the release of gliotransmitters
37. Conclusions

Topics Covered

• Astrocytes
• Functions of astroglia
• Adult neurogenesis
• The functional architecture of grey matter
• The blood-brain barrier and astrocytes
• Astroglial perivascular processes
• Mechanisms of molecular traffic through the blood-brain barrier
• Controlling microcirculation
• Metabolic support of neuronal networks
• Brain energetics
• The lactate shuffle
• Homeostatic function
• Water movements
• Signalling function
• Astroglia in synaptic transmission
• Astrocytes as secretory cells
• Distal signalling through the release of gliotransmitters

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 29, 2011
• Archived on April 28, 2022

Financial Disclosures

• Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.