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This talk introduces
inflamosomes,
using it as a basis for
further exploration
of the structure and
function of inflamosomes,
the types of triggers
that activate them,
and their central role in
both the innate immune response
and disease processes.
We will discuss how different
inflamosome sensors
detect various danger signals,
the downstream inflammatory
pathways they initiate,
and the consequences of
their dysregulation.
Finally, we will explore
current and emerging
therapies targeting
inflamosome activity in
chronic and
autoinflammatory diseases.
Inflamosomes are large
multi protein complexes
crucial to the innate
immune response,
acting as sentinels that
detect danger and infection.
A typical inflamosome consists
of a pattern
recognition receptor,
often NLRP three, an
adapter protein ASC,
and the effector
enzyme procaspase one.
Upon assembly, these components
form a distinctive
spec within the cell.
Each inflamosome subtype is
specialized to detect
specific danger signals,
helping the body recognize
a wide array of threats.
Inflamosomes are activated
by two main triggers,
pathogen associated
molecular patterns or PAMPs,
such as microbial ligands and
damage associated molecular
patterns or damps,
which are signals released
during cellular
stress or injury.
PAMPs include bacterial
LPS and viral RNA,
while damps comprise ATP,
uric acid crystals,
cholesterol crystals,
and amyloid beta.
The NLRP three inflammasom
